Oxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity response

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dc.authoridErbas, Oytun/0000-0001-5427-8428
dc.authoridKarabay Yavasoglu, N.Ulku/0000-0002-7483-0184
dc.authoridBUHUR, Aylin/0000-0002-3759-6616
dc.authoridYigitturk, Gurkan/0000-0002-5315-253X
dc.authoridYavasoglu, Altug/0000-0003-4227-1637
dc.contributor.authorSanci, Ebru
dc.contributor.authorKoksal Karayildirim, Cinel
dc.contributor.authorDagdeviren, Melih
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorBuhur, Aylin
dc.contributor.authorErbas, Oytun
dc.contributor.authorYavasoglu, Altug
dc.date.accessioned2024-08-31T07:50:28Z
dc.date.available2024-08-31T07:50:28Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractStreptozotocin (STZ) is used as a diabetes-inducing agent in experimental animal studies. However, it is known that STZ-induced diabetic animals show significant increases in oxidative stress parameters and neurodegeneration besides their blood glucose level. In this study, the acute and subacute toxic effects of STZ on the liver, sciatic nerve, and brain tissues were investigated in vivo rat model. Sprague-Dawley rats were divided into two groups; while 50 mg/kg STZ was administered ip to the STZ group, only saline was administered to the control group. After STZ administration, three units (100 U/mL) of subcutaneous insulin glargine were applied daily to prevent the formation of diabetes. At 24 h, 1,2, and 4 weeks after applications, rats from each group were sacrificed and tissues were removed under anesthesia. At the end of the study, compared to the control, a significant decrease in SOD and GST activity and an increase in lipid peroxidation were detected in the liver and sciatic tissues of rats in the STZ-treated group in the first 24h. Considering the TUNEL, NF kappa B, and NOS2 expressions, it was noted that while the effects of STZ on the liver were observed in the acute stage (24h), it had subacute effects on the brain. When apoptosis-related gene expression (Bcl-2, Bax, CASP3, CASP8, CASP9, TNF-alpha) and immunohistochemistry were evaluated, the apoptotic effect of STZ was observed mostly in sciatic nerve tissues. Within the scope of the study, it was revealed that STZ did not only show selective toxicity to pancreatic beta cells but also very toxic to other tissues and organs.en_US
dc.description.sponsorshipAliye Uster Foundation; Ege University, Scientific Research Foundation [15-FBe-003]en_US
dc.description.sponsorshipthis study was supported by the Aliye Uster Foundation and Ege University, Scientific Research Foundation (BaP Project number: 15-FBe-003).en_US
dc.identifier.doi10.1080/01480545.2024.2315150
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.pmid38348650en_US
dc.identifier.scopus2-s2.0-85185493367en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2024.2315150
dc.identifier.urihttps://hdl.handle.net/11454/105239
dc.identifier.wosWOS:001161235400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectStreptozotocinen_US
dc.subjectToxicityen_US
dc.subjectApoptosisen_US
dc.subjectRt-Pcren_US
dc.subjectImmunohistochemistryen_US
dc.titleOxidative stress and inflammatory markers in streptozotocin-induced acute and subacute toxicity responseen_US
dc.typeArticleen_US

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