Electrochemical Monitoring of Interaction of Temozolamide with DNA by Graphene Oxide Modified Single-Use Electrodes
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Electrochemical Soc Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Graphene oxide (GO) modified single-use pencil graphite electrodes (PGEs) were used for electrochemical monitoring of surface confined interaction between Temozolamide (TMZ) and calf thymus double stranded DNA (ctdsDNA). First, the PGE surface was activated by EDC/NHS (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide) as covalent agents (CA). Then, modification of GO was done onto the surface of chemically activated PGE surface to obtain CA-GO-PGEs. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy studies were used to establish the interfacial electron transfer of the electrodes. The optimization of experimental conditions was carried out via CV technique followed by electrochemical examination of the interaction of TMZ with ctdsDNA. (c) 2022 The Electrochemical Society (ECS). Published on behalf of ECS by IOP Publishing Limited.
Açıklama
Anahtar Kelimeler
Hplc Method, Rat Plasma, Temozolomide, Hybridization, Chitosan, Behavior, Drug
Kaynak
Journal Of The Electrochemical Society
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
169
Sayı
2
