RdRp mutations are associated with SARS-CoV-2 genome evolution

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dc.contributor.authorEskier, Doga
dc.contributor.authorKarakulah, Gokhan
dc.contributor.authorSuner, Asli
dc.contributor.authorOktay, Yavuz
dc.date.accessioned2020-12-01T11:58:55Z
dc.date.available2020-12-01T11:58:55Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractCOVID-19, caused by the novel SARS-CoV-2 virus, started in China in late 2019, and soon became a global pandemic. With the help of thousands of viral genome sequences that have been accumulating, it has become possible to track the evolution of the viral genome over time as it spread across the world. An important question that still needs to be answered is whether any of the common mutations affect the viral properties, and therefore the disease characteristics. Therefore, we sought to understand the effects of mutations in RNA-dependent RNA polymerase (RdRp), particularly the common 14408C>T mutation, on mutation rate and viral spread. By focusing on mutations in the slowly evolving M or E genes, we aimed to minimize the effects of selective pressure. Our results indicate that 14408C>T mutation increases the mutation rate, while the third-most common RdRp mutation, 15324C>T, has the opposite effect. It is possible that 14408C>T mutation may have contributed to the dominance of its co-mutations in Europe and elsewhere.en_US
dc.description.sponsorshipTurkish Academy of Sciences Young Investigator Program (TUBA-GEBIP)en_US
dc.description.sponsorshipYavuz Oktay is supported by the Turkish Academy of Sciences Young Investigator Program (TUBA-GEBIP). the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.doi10.7717/peerj.9587en_US
dc.identifier.issn2167-8359
dc.identifier.scopus2-s2.0-85094960679en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.7717/peerj.9587
dc.identifier.urihttps://hdl.handle.net/11454/62143
dc.identifier.volume8en_US
dc.identifier.wosWOS:000550577200014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPeerj Incen_US
dc.relation.ispartofPeerjen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSARS-CoV-2en_US
dc.subjectCOVID-19en_US
dc.subjectRNA-dependent RNA polymeraseen_US
dc.subjectRdRpen_US
dc.subjectMutation rateen_US
dc.titleRdRp mutations are associated with SARS-CoV-2 genome evolutionen_US
dc.typeArticleen_US

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