Chitotriosidase might be a diagnostic marker in patients with hashimoto thyroiditis

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dc.authorscopusid56548536700
dc.authorscopusid53664427700
dc.authorscopusid57936042000
dc.authorscopusid7004558658
dc.authorscopusid26656445700
dc.authorscopusid6505803191
dc.authorscopusid12041941200
dc.contributor.authorOzisik, H.
dc.contributor.authorSuner, A.
dc.contributor.authorCopur, O.
dc.contributor.authorSozmen, E.Y.
dc.contributor.authorYürekli, B.S.
dc.contributor.authorCetinkalp, S.
dc.contributor.authorOzgen, G.
dc.date.accessioned2024-08-25T18:51:39Z
dc.date.available2024-08-25T18:51:39Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: Hashimoto’s thyroiditis (HT) is the most common organ-specific autoimmune disease. The aim of our study was to investigate a possible role of chitotriosidase (Chito) activity as a potential marker of inflammation in diagnosis of patients with HT. In addition, we aimed to determine the levels of inflammation markers such as YKL-40, high sensitivity C-reactive protein (hsCRP) and oxidative stress (OS) parameters such as thiobarbituric acid reactive substances (TBARS), catalase (CAT), superoxide dismutase (SOD), GSH-Px to evaluate an association between those inflammatory and OS markers in patients with HT. Methods: 42 patients with HT and 28 control cases were studied. All cases were euthyroid. Chito activity was measured fluorometrically based on Hollak et al’s. method. hsCRP and YKL-40 levels were measured using ELISA. TBARS, SOD, and CAT activities were determined in hemolyzates. GSH-Px activity was determined by a colorimetric assay. Results: Higher Chito concentrations were observed in patients with HT compared to the control group (p=0.002). YKL-40 levels were detected higher in HT but it was not statistically significant (p=0.810). Chito levels were positively correlated with age and negatively correlated with SOD (r=0.360, p=0.021; r=-0.368, p=0.018). YKL-40 levels were positively correlated with FT3 and SOD in HT (r=0.324, p=0.037; r=0.312, p=0.044) and negatively correlated with age (r=?0.463, p=0.002). SOD levels were negatively correlated with age and positively correlated with YKL-40 (r=?0.371, p=0.016, r=0.312, p=0.044). Conclusion: We revealed that Chito levels were higher among euthyroid HT patients. This result may point out that Chito levels could be used as a potential marker of inflammation in HT. © 2023, Kare Publishing. All rights reserved.en_US
dc.description.sponsorshipreceived no financial support.en_US
dc.identifier.doi10.14744/ijmb.2022.36036
dc.identifier.endpage35en_US
dc.identifier.issn2587-2362
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85151869616en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage28en_US
dc.identifier.trdizinid1168661en_US
dc.identifier.urihttps://doi.org/10.14744/ijmb.2022.36036
dc.identifier.urihttps://hdl.handle.net/11454/102666
dc.identifier.volume6en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKare Publishingen_US
dc.relation.ispartofInternational Journal of Medical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectCatalaseen_US
dc.subjectchitotriosidaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjecthashimoto thyroiditisen_US
dc.subjectthiobarbituric acid reactive substancesen_US
dc.subjectYKL-40en_US
dc.titleChitotriosidase might be a diagnostic marker in patients with hashimoto thyroiditisen_US
dc.typeArticleen_US

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