Complex Structured Fluorescent Polythiophene Graft Copolymer as a Versatile Tool for Imaging, Targeted Delivery of Paclitaxel, and Radiotherapy

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dc.contributor.authorGuler, Emine
dc.contributor.authorAkbulut, Huseyin
dc.contributor.authorGeyik, Caner
dc.contributor.authorYilmaz, Tulay
dc.contributor.authorGumus, Z. Pinar
dc.contributor.authorBarlas, F. Baris
dc.contributor.authorAhan, Recep Erdem
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorYamada, Shuhei
dc.contributor.authorEndo, Takeshi
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T23:09:17Z
dc.date.available2019-10-27T23:09:17Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractAdvances in polymer chemistry resulted in substantial interest to utilize their diverse intrinsic advantages for biomedical research. Especially, studies on drug delivery for tumors have increased to a great extent. In this study, a novel fluorescent graft copolymer has been modified by a drug and targeting moiety and the resulting structure has been characterized by alterations in fluorescent intensity. The polythiophene based hybrid graft copolymer was synthesized by successive organic reactions and combination of in situ N-carboxy anhydride (NCA) ring opening and Suzuki coupling polymerization processes. Initially, targeted delivery of the graft copolymer was investigated by introducing a tumor specific ligand, anti-HER2/neu antibody, on the structure. The functionalized polymer was able to differentially indicate HER2-expressing A549 human lung carcinoma cells, whereas no signal was obtained for Vero, monkey kidney epithelial cells, and HeLa, human cervix adenocarcinoma cells. After integrating paclitaxel into the structure, cell viability, cell cycle progression, and radiosensitivity studies demonstrate HER2/neu targeting polymers inhibit cell proliferation. Importantly, the graft copolymer used had no cytotoxic effects to cells, as evidenced by cell viability and cell cycle analysis. This work clearly confirms that a specially designed and fabricated graft copolymer with a highly complex structure is a promising theranostic agent capable of targeting tumor cells for diagnostic and therapeutic purposes.en_US
dc.identifier.doi10.1021/acs.biomac.6b00491en_US
dc.identifier.endpage2408en_US
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.issue7en_US
dc.identifier.pmid27305462en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2399en_US
dc.identifier.urihttps://doi.org/10.1021/acs.biomac.6b00491
dc.identifier.urihttps://hdl.handle.net/11454/52595
dc.identifier.volume17en_US
dc.identifier.wosWOS:000379637800010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofBiomacromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleComplex Structured Fluorescent Polythiophene Graft Copolymer as a Versatile Tool for Imaging, Targeted Delivery of Paclitaxel, and Radiotherapyen_US
dc.typeArticleen_US

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