Effects of silk sericin on incision wound healing in a dorsal skin flap wound healing rat model

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dc.contributor.authorErsel M.
dc.contributor.authorUyanikgil Y.
dc.contributor.authorAkarca F.K.
dc.contributor.authorOzcete E.
dc.contributor.authorAltunci Y.A.
dc.contributor.authorKarabey F.
dc.contributor.authorCavusoglu T.
dc.contributor.authorMeral A.
dc.contributor.authorYigitturk G.
dc.contributor.authorCetin E.O.
dc.date.accessioned2019-10-27T08:20:39Z
dc.date.available2019-10-27T08:20:39Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The wound healing process is complex and still poorly understood. Sericin is a silk protein synthesized by silk worms (Bombyx mori). The objective of this study was to evaluate in vivo wound healing effects of a sericincontaining gel formulation in an incision wound model in rats. Material/Methods: Twenty-eight Wistar-Albino rats were divided into 4 groups (n=7). No intervention or treatment was applied to the Intact control group. For other groups, a dorsal skin flap (9×3 cm) was drawn and pulled up with sharp dissection. The Sham operated group received no treatment. The Placebo group received placebo gel without sericin applied to the incision area once a day from day 0 to day 9. The Sericin Group 3 received 1% sericin gel applied to the incision area once a day from day 0 to day 9. Hematoxylin and eosin stain was applied for histological analysis and Mallory-Azan staining was applied for histoimmunochemical analysis of antibodies and iNOS (inducible nitric oxide synthase), and desmin was applied to paraffin sections of skin wound specimens. Parameters of oxidative stress were measured in the wound area. Results: Epidermal thickness and vascularization were increased, and hair root degeneration, edema, cellular infiltration, collagen discoloration, and necrosis were decreased in Sericin group in comparison to the Placebo group and the Sham operated group. Malonyldialdehyde (MDA) levels were decreased, but superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were increased in the sericin group. Conclusions: We found that sericin had significant positive effects on wound healing and antioxidant activity. Sericin-based formulations can improve healing of incision wounds. © Med Sci Monit.en_US
dc.identifier.doi10.12659/MSM.897981en_US
dc.identifier.endpage1078en_US
dc.identifier.issn1234-1010
dc.identifier.pmid27032876en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1064en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.897981
dc.identifier.urihttps://hdl.handle.net/11454/25744
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInternational Scientific Literature Inc.en_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectSericinsen_US
dc.subjectWound healingen_US
dc.titleEffects of silk sericin on incision wound healing in a dorsal skin flap wound healing rat modelen_US
dc.typeArticleen_US

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