Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency

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dc.authoridTimarcı Becerik, Ilgın/0000-0002-1135-6657
dc.authoridPalamar, Melis/0000-0002-2494-0131
dc.authoridkorkmaz, ilayda/0000-0001-8043-8632
dc.authoridEgrilmez, Sait/0000-0002-6971-527X
dc.contributor.authorKorkmaz, Ilayda
dc.contributor.authorPalamar, Melis
dc.contributor.authorTimarci, Ilgin
dc.contributor.authorEgrilmez, Sait
dc.contributor.authorYagci, Ayse
dc.contributor.authorSelver, Ozlem Barut
dc.date.accessioned2024-08-31T07:49:55Z
dc.date.available2024-08-31T07:49:55Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractPurposeTo evaluate limbal graft transplantation success in pediatric patients with chemical injury-induced limbal stem cell deficiency (LSCD) using the 'LSCD Working Group' staging system.MethodsMedical records of 11 eyes of 11 children who underwent limbal graft transplantation (limbal autograft/limbal allograft) were included. Surgical success was defined as improvement in the post-operative 1st year LSCD stage.ResultsThe mean age was 12 +/- 5 (4-17) years. Causative agent was alkaline in 4(36.4%) and acid in 3(27.2%) patients. Limbal autograft was performed in 9 (81.8%) eyes with unilateral LSCD, and allograft transplantation was performed in 2 (18.2%) eyes with bilateral LSCD. The mean follow-up time was 33.89 +/- 30.73 (12-102.33) months. The overall limbal graft transplantation success rate was 72.7%. Among 9 patients who receive limbal autograft, 8 had improvement in post-operative LSCD stage, 1 had stable LSCD stage. Of the 2 patients who receive limbal allograft, post-operative LSCD stage remained the same in 1 and worsened in 1 patient. The mean time between injury and the surgery was 30.47 +/- 30.08 (7-108.47) months. Penetrating keratoplasty was performed in 3 (27.2%) of 11 patients following limbal graft transplantation.ConclusionManagement of LSCD in children is challenging and appears to be somewhat different from that of adults. Limited data in the literature indicate that cultivated or simple limbal epithelial transplantations (CLET/SLET) are primarily preferred in children. Although the tendency to take small tissue from the healthy eye is noteworthy, conventional limbal allograft and autograft transplantations also show promising results without any further complications in at least 1 year follow-up period.en_US
dc.description.sponsorshipDAS:No datasets were generated or analysed during the current study.en_US
dc.identifier.doi10.1007/s10792-024-03269-5
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue1en_US
dc.identifier.pmid39093517en_US
dc.identifier.scopus2-s2.0-85200213179en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-024-03269-5
dc.identifier.urihttps://hdl.handle.net/11454/105029
dc.identifier.volume44en_US
dc.identifier.wosWOS:001284595900002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectOcular Chemical Injuryen_US
dc.subjectLimbal Stem Cell Deficiencyen_US
dc.subjectLimbal Graft Transplantationen_US
dc.subjectPediatric Patientsen_US
dc.subjectSurgical Success Rateen_US
dc.titleLimbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiencyen_US
dc.typeArticleen_US

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