Assessment of disease activity and progression in Takayasu's arteritis with Disease Extent Index-Takayasu

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dc.contributor.authorAydin, Sibel Z.
dc.contributor.authorYilmaz, Neslihan
dc.contributor.authorAkar, Servet
dc.contributor.authorAksu, Kenan
dc.contributor.authorKamali, Sevil
dc.contributor.authorYucel, Eftal
dc.contributor.authorKaradag, Omer
dc.contributor.authorBicakcigil, Muge
dc.contributor.authorOzer, Huseyin
dc.contributor.authorKiraz, Sedat
dc.contributor.authorOnen, Fatos
dc.contributor.authorInanc, Murat
dc.contributor.authorKeser, Gokhan
dc.contributor.authorAkkoc, Nurullah
dc.contributor.authorDireskeneli, Haner
dc.date.accessioned2019-10-27T21:14:46Z
dc.date.available2019-10-27T21:14:46Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. Disease Extent Index-Takayasu (DEI.Tak) is a new index developed for the follow-up of Takayasu's arteritis ( TA), assessing only clinical findings without the requirement of imaging. We investigated the effectiveness of DEI.Tak in assessing disease activity and progression by comparing with physician's global assessment ( PGA) and active disease criteria defined by Kerr et al. Methods. The initial DEI.Tak forms were filled in for 145 TA patients cross-sectionally to detect the baseline damage and after 29.8 (31) months (n = 105, 144 visits) only by including the new/worsening symptoms within the past 6 months. Results. At baseline, all patients had a DEI.Tak > 0 [mean (s.d.): 7.6 (4.2)]. At this evaluation, 62% of the patients had active, 16.2% had persistent and 21.8% had inactive disease according to the PGA. At follow-up, in 69% of the patients the DEI.Tak score was 0. However, 14% of them were accepted as having active and 17% persistent disease according to PGA. In contrast, 18% with a DEI.Tak epsilon 1 were inactive according to PGA. Patients with active or persistent disease with PGA had higher DEI.Tak compared with inactives [1.3 (1.9), 1 (1.3) vs 0.2 (0.6), respectively; P < 0.001]. According to Kerr's criteria 27% were active. The total agreement between DEI.Tak and Kerr's criteria was 94% (kappa = 0.85). Compared with PGA, Kerr's criteria had a total agreement of 74% and DEI.Tak 68%. Conclusion. During follow-up, most TA patients showed no clinical activity with DEI-Tak. Although the agreement between Kerr's criteria and DEI.Tak seemed very good, using Kerr's criteria instead of DEI.Tak increased the consistency with PGA, which could be explained by the influence of imaging data and acute-phase reactant levels on the physician's decisions.en_US
dc.identifier.doi10.1093/rheumatology/keq171en_US
dc.identifier.endpage1893en_US
dc.identifier.issn1462-0324
dc.identifier.issue10en_US
dc.identifier.pmid20542893en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1889en_US
dc.identifier.urihttps://doi.org/10.1093/rheumatology/keq171
dc.identifier.urihttps://hdl.handle.net/11454/43439
dc.identifier.volume49en_US
dc.identifier.wosWOS:000281954700013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofRheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTakayasu arteritisen_US
dc.subjectDisease activityen_US
dc.subjectDEIen_US
dc.subjectTaken_US
dc.subjectBirmingham vasculitis activity scoreen_US
dc.titleAssessment of disease activity and progression in Takayasu's arteritis with Disease Extent Index-Takayasuen_US
dc.typeArticleen_US

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