Diurnal changes of critical flicker frequency in patients with liver cirrhosis and their relationship with sleep disturbances

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dc.contributor.authorGencdal, Genco
dc.contributor.authorGunsar, Fulya
dc.contributor.authorMeral, Cenk Emre
dc.contributor.authorSalman, Esin
dc.contributor.authorGursel, Berna
dc.contributor.authorOruc, Nevin
dc.contributor.authorKarasu, Zeki
dc.contributor.authorErsoz, Galip
dc.contributor.authorAkarca, Ulus S.
dc.date.accessioned2019-10-27T22:12:28Z
dc.date.available2019-10-27T22:12:28Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: We aimed to measure the diurnal changes of critical flicker frequency in healthy subjects and cirrhotic patients and to investigate their relationship with sleep disturbance. Methods: Cirrhotic patients and healthy volunteers were included. All groups completed the Pittsburgh Sleep Quality Index and a simple sleep questionnaire. Sleep disturbance was defined as a Pittsburgh Sleep Quality Index score of >5. Critical flicker frequency was measured twice a day to detect diurnal abnormalities. Results: Overall, 59 cirrhotic patients (54.2% males, Mean Age 59 +/- 11 years) and 18 controls (39.9% males, Mean Age 58 +/- 9 years) were included. Sleep disturbances were more common in cirrhotics (66.1%) than controls (38.9%, p < 0.05). In cirrhotics, the critical flicker frequency was not related to decompensation. The nocturnal values were higher than the morning values in cirrhotics (64.4%), but not in controls (p < 0.0001). Additionally, sleep disturbances were more common in cirrhotics who had higher nocturnal values (p < 0.05). Conclusions: Changes in the diurnal critical flicker frequency were observed in cirrhotics but not in controls. Sleep disturbances in cirrhotics appear to be associated with deviations of the diurnal rhythm of critical flicker frequency rather than with clinical parameters such as the clinical stages of cirrhosis and the Model For End-Stage Liver Disease and Child-Pugh scores. (C) 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.dld.2014.08.031en_US
dc.identifier.endpage1115en_US
dc.identifier.issn1590-8658
dc.identifier.issn1878-3562
dc.identifier.issue12en_US
dc.identifier.pmid25192605en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1111en_US
dc.identifier.urihttps://doi.org/10.1016/j.dld.2014.08.031
dc.identifier.urihttps://hdl.handle.net/11454/49448
dc.identifier.volume46en_US
dc.identifier.wosWOS:000345234100012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofDigestive and Liver Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCirrhosisen_US
dc.subjectCritical flicker frequencyen_US
dc.subjectSleep disturbancesen_US
dc.titleDiurnal changes of critical flicker frequency in patients with liver cirrhosis and their relationship with sleep disturbancesen_US
dc.typeArticleen_US

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