Edaravone Leads To Increased Internal Luminal Vascular Circumference Following Subarachnoid Hemorrhage in An Animal Model of Vasospasm
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Tarih
2012
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info:eu-repo/semantics/openAccess
Özet
Amaç: Serebral vazospazm subaraknoid kanamada mortalite ve morbiditenin önemli nedenlerinden biridir. Klinik ve laboratuar çalışmalarda bir çok faktör denenmesine rağmen, vazospazm gelişiminde etkili ajanlar tam olarak anlaşılamamıştır. Bu çalışmada antioksidan ajan olan edaravone'un, hayvan subaraknoid kanama modelinde vazospazm üzerindeki olası azaltıcı etkisi sunulmuştur. Gereç ve yöntemler: Çalışmada rat baziler arter subaraknoid kanama modeli kullanıldı. Ratlar 3 grubu ayrıldı. Grup-1: Şam grubu (n=7 rat), Grup=2: Subaraknoid kanama grubu (n=7 rat), Grup=3: Subaraknoid kanama + Edaravone grubu (4 mg/kg intraperitoneal) (n=7 rat). Yedinci günde rat beyinleri çıkarılıp baziler arter ışık mikroskobisi altında incelendi. Baziler arter iç lümen çevresi her üç grup için karşılaştırıldı. Bulgular: Damar iç lümen çevresi en geniş grup 1 de olup bunu grup 3 ve grup 2 takip etti. Grup 3 ün iç lümen çevresi grup 2 ye göre %2 daha fazla olmasına rağmen istatistiksel olarak anlamlı değildi. Sonuç: Bu hayvan vazospazm modeli, edaravone'un subaraknoid kanama sonrasında oluşan vazospazmda damar iç lümen çevresini genişlettiğini göstermiştir.Edaravone un bu etkisi, lipid peroksidasyonunu engelleyerek oksihemoglobin ve reaktif oksijen ürünlerinin etkisini azaltmasına bağlı olabilir.
Purpose: Cerebral vasospasm is the leading cause of morbidity and mortality following subarachnoid hemorrhage. Although a number of factors have been examined in clinical and experimental studies, the agent(s) responsible for developing and diminishing vasospasm remain poorly understood. Here, the role of edaravone, an antioxidant agent, was evaluated for its ability to diminish vasospasm in an animal model of subarachnoid hemorrhage. Materials and Methods: A rat basilar artery subarachnoid hemorrhage model was used. Rats were divided into three groups: sham (n=7; Group 1), subarachnoid hemorrhage (n=7 Group 2), and subarachnoid hemorrhage plus edaravone (4 mg/kg intraperitoneally, n=7; Group 3). At the end of the seventh day, the rats were sacrificed, their brains were removed, and sections were taken from the basilar artery. These were examined using a light microscope, comparing the internal luminal circumference of the basilar artery of each group. Results: The circumference was largest in Group 1, followed by Group 3 and then Group 2. That of Group 3 was 2% higher than that of Group 2, but this difference was not statistically significant. Conclusion: This animal model for vasospasm suggests that edaravone helps enlarge internal luminal circumference following vasospasm caused by subarachnoid hemorrhage. It may do this by blocking lipid peroxidation and thereby reducing the effects of oxyhemoglobin and reactive oxygen species.
Purpose: Cerebral vasospasm is the leading cause of morbidity and mortality following subarachnoid hemorrhage. Although a number of factors have been examined in clinical and experimental studies, the agent(s) responsible for developing and diminishing vasospasm remain poorly understood. Here, the role of edaravone, an antioxidant agent, was evaluated for its ability to diminish vasospasm in an animal model of subarachnoid hemorrhage. Materials and Methods: A rat basilar artery subarachnoid hemorrhage model was used. Rats were divided into three groups: sham (n=7; Group 1), subarachnoid hemorrhage (n=7 Group 2), and subarachnoid hemorrhage plus edaravone (4 mg/kg intraperitoneally, n=7; Group 3). At the end of the seventh day, the rats were sacrificed, their brains were removed, and sections were taken from the basilar artery. These were examined using a light microscope, comparing the internal luminal circumference of the basilar artery of each group. Results: The circumference was largest in Group 1, followed by Group 3 and then Group 2. That of Group 3 was 2% higher than that of Group 2, but this difference was not statistically significant. Conclusion: This animal model for vasospasm suggests that edaravone helps enlarge internal luminal circumference following vasospasm caused by subarachnoid hemorrhage. It may do this by blocking lipid peroxidation and thereby reducing the effects of oxyhemoglobin and reactive oxygen species.
Açıklama
Anahtar Kelimeler
Nörolojik Bilimler
Kaynak
Journal of Neurological Sciences (Turkish)
WoS Q Değeri
Scopus Q Değeri
Cilt
29
Sayı
4
