Association between mannose binding lectin polymorphisms and predisposition to bacterial meningitis

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dc.contributor.authorVardar, Fadil
dc.contributor.authorPehlivan, Sacide
dc.contributor.authorOnay, Hueseyin
dc.contributor.authorAthhan, Fuesun
dc.contributor.authorGueliz, Nesrin
dc.contributor.authorOezkinay, Cihangir
dc.contributor.authorOezkinay, Ferda
dc.date.accessioned2019-10-27T19:33:50Z
dc.date.available2019-10-27T19:33:50Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to examine the presence of any association between mannose binding lectin (MBL) gene variants and bacterial meningitis. Codon 54 (B allele) and codon 57 (C allele) polymorphisms in exon 1 of the MBL gene were investigated in 50 healthy controls and 31 patients diagnosed as purulent meningitis. Codon 57 polymorphism was not found in our patient and control groups. B allele frequency was significantly higher in the patient group (22%) compared to the control group (3%). AB genotype was determined in 39% and 6% of patient and healthy control groups, respectively, and the difference was statistically significant. AA genotype was determined in 61% of the patient group and in 94% of the control group, and it was statistically low in the patient group. These results suggest that codon 54 polymorphism in the MBL gene may play a role in susceptibility to bacterial meningitis in children.en_US
dc.identifier.endpage273en_US
dc.identifier.issn0041-4301
dc.identifier.issue3en_US
dc.identifier.pmid17990579en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage270en_US
dc.identifier.urihttps://hdl.handle.net/11454/39536
dc.identifier.volume49en_US
dc.identifier.wosWOS:000250163900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmannose binding lectinen_US
dc.subjectbacterial meningitisen_US
dc.subjectsusceptibilityen_US
dc.subjectpolymorphismen_US
dc.titleAssociation between mannose binding lectin polymorphisms and predisposition to bacterial meningitisen_US
dc.typeArticleen_US

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