Comparison of the effects of new and conventional hormone replacement therapies on left ventricular diastolic function in healthy postmenopausal women: a Doppler and ultrasonic backscatter study

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dc.contributor.authorDuygu, Hamza
dc.contributor.authorAkman, Levent
dc.contributor.authorOzerkan, Filiz
dc.contributor.authorAkercan, Fuat
dc.contributor.authorZoghi, Mehdi
dc.contributor.authorNalbantgil, Sanem
dc.contributor.authorErturk, Umit
dc.contributor.authorAkilli, Azem
dc.contributor.authorOnder, Remzi
dc.contributor.authorAkin, Mustafa
dc.date.accessioned2019-10-27T20:52:46Z
dc.date.available2019-10-27T20:52:46Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractWe aimed to compare the effects of new treatment modalities to conventional hormone replacement therapy (HRT) on left ventricular (LV) diastolic function, by means of conventional and tissue Doppler echocardiography and the myocardial integrated backscatter (IBS) in postmenopausal women. One hundred and fifty healthy postmenopausal women were included in this study. Subjects were assigned to one of the five groups receiving 1 year of treatment (estrogen, estrogen plus progesterone, raloxifene, tibolone or placebo). E and A wave velocity, E/A ratio, isovolumic relaxation time (IVRT), deceleration time (DT), peak early (Em) diastolic mitral annular velocity, E/Em ratio, the cyclic variation of integrated backscatter (CVIBS) and the mean value of the IBS signal (MIBS) were determined before and 12 months after therapy. E (76 +/- A 10 vs. 98 +/- A 8 cm/s, P = 0.0001 and 78 +/- A 10 vs. 90 +/- A 12 cm/s, P = 0.02, respectively), Em (14.3 +/- A 2.4 vs. 16.4 +/- A 2.5 cm/s, P = 0.001 and 15.1 +/- A 3.4 vs. 16.2 +/- A 3.5 cm/s, P = 0.01, respectively), and E/A ratio (1.15 +/- A 0.3 vs. 1.42 +/- A 0.4, P = 0.0001 and 1.0 +/- A 0.2 vs. 1.22 +/- A 0.2, P = 0.01, respectively) were increased significantly compared to pretreatment in both estrogen and raloxifene groups while DT, A, E/Em, and IVRT were significantly decreased. A significant increase in CVIBS and decrease in MIBS were detected 12 months after estrogen and raloxifene administration while no significant changes were observed in other groups. Changes in the MIBS and CVIBS were found to be independently associated with the observed changes in the diastolic function indexes during therapy. Both estrogen and raloxifene regimens may improve LV diastolic functions in healthy postmenopausal women. This improvement may be a result of direct cardiac effects on LV myocardium.en_US
dc.identifier.doi10.1007/s10554-009-9429-2en_US
dc.identifier.endpage396en_US
dc.identifier.issn1569-5794
dc.identifier.issue4en_US
dc.identifier.pmid19194783en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage387en_US
dc.identifier.urihttps://doi.org/10.1007/s10554-009-9429-2
dc.identifier.urihttps://hdl.handle.net/11454/43265
dc.identifier.volume25en_US
dc.identifier.wosWOS:000264334000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Journal of Cardiovascular Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMenopauseen_US
dc.subjectHormone replacement therapyen_US
dc.subjectDiastolic functionen_US
dc.subjectIntegrated backscatteren_US
dc.titleComparison of the effects of new and conventional hormone replacement therapies on left ventricular diastolic function in healthy postmenopausal women: a Doppler and ultrasonic backscatter studyen_US
dc.typeArticleen_US

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