Electrospun Nanofibers Loaded with Marigold Extract Based on PVP/HP?CD and PCL/PVP Scaffolds for Wound Healing Applications

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dc.authoridKarpi?ski, Tomasz M./0000-0001-6599-9204
dc.authoridErdem, Cansu/0009-0006-2088-2508
dc.authoridRosiak, Natalia/0000-0003-4722-6413
dc.authoridMiklaszewski, Andrzej/0000-0001-6792-4281
dc.authoridPaczkowska-Walendowska, Magdalena/0000-0002-0418-9336
dc.contributor.authorPaczkowska-Walendowska, Magdalena
dc.contributor.authorRosiak, Natalia
dc.contributor.authorPlech, Tomasz
dc.contributor.authorKarpinski, Tomasz M.
dc.contributor.authorMiklaszewski, Andrzej
dc.contributor.authorWitkowska, Katarzyna
dc.contributor.authorJaskolski, Maciej
dc.date.accessioned2024-08-31T07:49:39Z
dc.date.available2024-08-31T07:49:39Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractMarigold flower is a traditionally used plant material topically applied on the skin due to its anti-inflammatory properties and antibacterial activity. This potential of action justifies the implementation of marigold extract in nanofiber scaffolds based on poly-vinylpyrrolidone/hydroxypropyl-beta-cyclodextrin (PVP/HP beta CD) and polycaprolactone/polyvinylpyrrolidone (PCL/PVP) obtained by electrospinning for wound treatment. Using SEM, the morphology of electrospun scaffolds showed a fiber diameter in the range of 298-527 nm, with a uniform and bead-free appearance. ATR-FTIR spectroscopy confirmed the presence of marigold extracts in nanofibrous scaffolds. The composition of the nanofibers can control the release; in the case of PVP/HP beta CD, immediate release of 80% of chlorogenic acid (an analytical and functional marker for marigold extract) was achieved within 30 min, while in the case of PCL/PVP, the controlled release was achieved within 24 h (70% of chlorogenic acid). All systems showed weak antibacterial activity against skin and wound-infecting bacteria Staphylococcus aureus (MIC 100 mg/mL), and Pseudomonas aeruginosa (MIC 200 mg/mL) and yeasts Candida albicans (MIC 100 mg/mL). Analysis of the effect of different scaffold compositions of the obtained electrofibers showed that those based on PCL/PVP had better wound healing potential. The scratch was closed after 36 h, compared to the 48 h required for PVP/HP beta CD. Overall, the study shows that scaffolds of PCL/PVP nanofibers loaded with classic marigold extract have the best potential as wound dressing materials because of their ability to selectively modulate inflammation (via inhibition of hyaluronidase enzyme) and supportive antimicrobial properties, thereby aiding in the early stages of wound healing and repair.en_US
dc.description.sponsorshipNational Science Centeren_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.3390/ma17081736
dc.identifier.issn1996-1944
dc.identifier.issue8en_US
dc.identifier.pmid38673093en_US
dc.identifier.scopus2-s2.0-85191395176en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/ma17081736
dc.identifier.urihttps://hdl.handle.net/11454/104936
dc.identifier.volume17en_US
dc.identifier.wosWOS:001211230000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMaterialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectMarigold Floweren_US
dc.subjectCalendulae Flosen_US
dc.subjectChlorogenic Aciden_US
dc.subjectNanofibersen_US
dc.subjectElectrospinningen_US
dc.subjectWound Healingen_US
dc.titleElectrospun Nanofibers Loaded with Marigold Extract Based on PVP/HP?CD and PCL/PVP Scaffolds for Wound Healing Applicationsen_US
dc.typeArticleen_US

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