Evaluation of unusual and highly aggressive variant of endometrium cancer: nonendometrioid endometrium carcinoma of the uterus

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dc.contributor.authorSert, Fatma
dc.contributor.authorYilmaz, Ugur
dc.contributor.authorAlanyali, Senem
dc.contributor.authorAras, Arif
dc.contributor.authorOzsaran, Zeynep
dc.date.accessioned2019-10-27T10:48:16Z
dc.date.available2019-10-27T10:48:16Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractAims: To evaluate the survival and treatment outcomes of patients with nonendometrioid endometrium carcinoma after postoperative radiotherapy. Methods: The records of 94 patients treated with postoperative radiotherapy (RT) between January 2005 and December 2011 were retrospectively reviewed. Postoperative RT was delivered with a dose of 45-50.4 Gy with 1.8 Gy daily fractions and brachytherapy was added to external RT for 62 patients with a dose of 3 x 6 Gy. Median follow-up time was 35 months (range 6-95 months). Results: Median age was 63 years (range 43-83 years) and lymph node metastasis (LNM) was positive in 15 (16.0%) patients. The stage distribution of the patients was as follows: stage I, 58 (61.7%); stage II, 16 (17.0%); stage III, 18 (19.1%); stage IV, 2 (2.2%). Five-year locoregional control (LRC), disease-free survival (DFS), and overall survival (OS) rates were 92.3%, 68.2%, and 78.6%, respectively. In univariable analysis, it was determined that the factors affecting OS rates were stage (p = 0.003), presence of LNM (p = 0.003), and presence of lymphovascular space invasion (LVSI) (p = 0.007); factors affecting DFS rates were stage (p = 0.019), presence of LVSI (p = 0.002), and having LNM (p = 0.049); and the factor affecting LRC rates was tumor size (>5 cm) (p = 0.011). In subgroup analyses, among all stage I patients, the DFS rates were lower for those with histologic grade 3 tumors and more than 1/2 myometrial invasion. Conclusions: Due to its rarity, the prognostic factors and outcomes of nonendometioid endometrium carcinoma are not fully understood. In our analysis, stage, LNM, and presence of LVSI were found to be the most important prognostic factors. In order to tailor the optimal treatment strategy, prospective studies are needed.en_US
dc.identifier.doi10.5301/tj.5000404en_US
dc.identifier.endpage556en_US
dc.identifier.issn0300-8916
dc.identifier.issn2038-2529
dc.identifier.issue6en_US
dc.identifier.pmid26391760en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage551en_US
dc.identifier.urihttps://doi.org/10.5301/tj.5000404
dc.identifier.urihttps://hdl.handle.net/11454/31520
dc.identifier.volume103en_US
dc.identifier.wosWOS:000416789800009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWichtig Publishingen_US
dc.relation.ispartofTumorien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectClear cell endometrium carcinomaen_US
dc.subjectNonendometriod endometrium carcinomaen_US
dc.subjectRadiotherapyen_US
dc.subjectSerous papillary endometrium carcinomaen_US
dc.subjectType 2 endometrium carcinomaen_US
dc.titleEvaluation of unusual and highly aggressive variant of endometrium cancer: nonendometrioid endometrium carcinoma of the uterusen_US
dc.typeArticleen_US

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