Does Helicobacter pylori infection have a role in coronary artery disease?
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/aims: Various infectious diseases have been linked to coronary artery disease on epidemiological and pathogenic grounds. The aim of this study was to investigate the relationship between Helicobacter pylori infection and coronary artery disease. Methods: A total of 170 consecutive cases undergoing coronary angiography at Ege University Cardiology Department were included in the study. Seroprevalence of Helicobacter pylori infection and antibodies to cagA and plasma levels of fibrinogen, vitamin B12, folic acid and homocysteine were then evaluated. Results: Coronary artery disease was diagnosed in 114 (67.1%) cases by angiography. Anti-Helicobacter pylori IgG was found to be positive in 83 (72.8%) cases with coronary artery disease and in 46 (82.1%) of those without it (p>0.05). Among 129 Helicobacter pylori-positive subjects, antibodies to cagA were detected in 53% (44/83) of the cases with coronary artery disease and in 52.2% (24/46) of those without the disease (p>0.05). Plasma levels of vitamin B12 were significantly lower in coronary artery disease cases than in those without it (224.1±108.5 and 275.8±197.7 pmol/l respectively, p=0.029), while homocysteine levels were significantly higher in coronary artery disease cases than in those without (14.9±5.2 and 12.8±4.8 mmol/l, respectively, p=0.012) it. No significant difference was detected between the cases with and without coronary artery disease in terms of fibrinogen and folate levels and none of the parameters studied showed any significant difference between Helicobacter pylori seropositive and seronegative groups. However, plasma vitamin B12 levels were found to be significantly lower in the cagA positive group than in cagA negative cases (209.6±104.2 and 252.9±109.8 pmol/l, respectively, p=0.023). Conclusions: In this study, no significant difference was detected between cases with and without coronary artery disease in terms of Helicobacter pylori and cagA seropositivity rates. The detection of lower vitamin B12 and higher homocysteine levels in patients with coronary artery disease suggests the role of vitamin B12 deficiency in its pathogenesis. Lower vitamin B12 levels found in cagA-positive cases also suggests that infection with cagA-positive Helicobacter pylori strains might contribute to the development of coronary artery disease by decreasing vitamin B12 absorption.
Açıklama
Anahtar Kelimeler
cagA, Coronary artery disease, Fibrinogen, Folic acid, Helicobacter pylori, Homocysteine, Vitamin B12
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
12
Sayı
4
