Activation properties of trigeminal motoneurons in participants with and without bruxism

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dc.contributor.authorD'Amico, Jessica M.
dc.contributor.authorYavuz, S. Utku
dc.contributor.authorSaracoglu, Ahmet
dc.contributor.authorAtis, Elif Sibel
dc.contributor.authorGorassini, Monica A.
dc.contributor.authorTurker, Kemal S.
dc.date.accessioned2019-10-27T22:06:46Z
dc.date.available2019-10-27T22:06:46Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractIn animals, sodium-and calcium-mediated persistent inward currents (PICs), which produce long-lasting periods of depolarization under conditions of low synaptic drive, can be activated in trigeminal motoneurons following the application of the monoamine serotonin. Here we examined if PICs are activated in human trigeminal motoneurons during voluntary contractions and under physiological levels of monoaminergic drive (e. g., serotonin and norepinephrine) using a paired motor unit analysis technique. We also examined if PICs activated during voluntary contractions are larger in participants who demonstrate involuntary chewing during sleep (bruxism), which is accompanied by periods of high monoaminergic drive. In control participants, during a slowly increasing and then decreasing isometric contraction, the firing rate of an earlier-recruited masseter motor unit, which served as a measure of synaptic input to a later-recruited test unit, was consistently lower during derecruitment of the test unit compared with at recruitment (Delta F = 4.6 +/- 1.5 imp/s). The Delta F, therefore, is a measure of the reduction in synaptic input needed to counteract the depolarization from the PIC to provide an indirect estimate of PIC amplitude. The range of Delta F values measured in the bruxer participants during similar voluntary contractions was the same as in controls, suggesting that abnormally high levels of monoaminergic drive are not continually present in the absence of involuntary motor activity. We also observed a consistent "onion skin effect" during the moderately sized contractions (<20% of maximal), whereby the firing rate of higher threshold motor units discharged at slower rates (by 4-7 imp/s) compared with motor units with relatively lower thresholds. The presence of lower firing rates in the more fatigue-prone, higher threshold trigeminal motoneurons, in addition to the activation of PICs, likely facilitates the activation of the masseter muscle during motor activities such as eating, nonnutritive chewing, clenching, and yawning.en_US
dc.description.sponsorshipCanadian Institute of Health ResearchCanadian Institutes of Health Research (CIHR) [MOP-106549]; Turkish Scientific and Technological Research OrganizationTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [Tubitak-107S029- SBAG-3556]; Alberta Innovates: Health Solutions; Alberta Paraplegic Foundation; European Research Council (ERC) via the ERC Advanced Grant DEMOVEEuropean Research Council (ERC) [267888]en_US
dc.description.sponsorshipThis work was supported by the Canadian Institute of Health Research (MOP-106549; to M. A. Gorassini) and a Turkish Scientific and Technological Research Organization (Tubitak-107S029- SBAG-3556) grant (to K. S. Turker). Salary support was provided by Alberta Innovates: Health Solutions (to M. A. Gorassini and J. M. D'Amico) and the Alberta Paraplegic Foundation (to J. M. D'Amico), and S,.U. Yavuz was supported by the European Research Council (ERC) via the ERC Advanced Grant DEMOVE (No. 267888).en_US
dc.identifier.doi10.1152/jn.00536.2013en_US
dc.identifier.endpage2872en_US
dc.identifier.issn0022-3077
dc.identifier.issn1522-1598
dc.identifier.issue12en_US
dc.identifier.pmid24068753en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2863en_US
dc.identifier.urihttps://doi.org/10.1152/jn.00536.2013
dc.identifier.urihttps://hdl.handle.net/11454/48879
dc.identifier.volume110en_US
dc.identifier.wosWOS:000328889700016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Physiological Socen_US
dc.relation.ispartofJournal of Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmotoneuronsen_US
dc.subjectpainen_US
dc.subjectsleep bruxismen_US
dc.subjectplateausen_US
dc.titleActivation properties of trigeminal motoneurons in participants with and without bruxismen_US
dc.typeArticleen_US

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