Effects of selective cyclooxygenase-2 inhibition on gingival tissue levels of prostaglandin E2 and prostaglandin F2? and clinical parameters of chronic periodontitis

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dc.contributor.authorVardar S.
dc.contributor.authorBaylas H.
dc.contributor.authorHuseyinov A.
dc.date.accessioned2019-10-27T08:59:49Z
dc.date.available2019-10-27T08:59:49Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The purpose of the present study was to evaluate the effect of a relatively selective cyclooxygenase (COX)-2 inhibitor (nimesulide) and non-selective COX-1/COX-2 inhibitor (naproxen) used as an adjunct to non-surgical (scaling and root planing [SRP]) periodontal therapy in chronic periodontitis patients on the gingival tissue (GT) levels of prostaglandin (PG)E2 and PGF2?. Methods: Thirty patients with chronic periodontitis were divided into 3 groups of 10 each. One group received 100 mg of nimesulide; one received 275 mg of naproxen sodium; and the third group received placebo tablets in a 2 _xt 1 regimen for 10 days as an adjunct to SRP. GT samples were obtained before drug intake and on day 10. Plaque index (PI) and papillary bleeding index (PBI) scores were recorded at baseline, day 10, and at 3 months; probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and at 3 months. The levels of PGE2 were detected using an enzyme immunoassay (EIA), and the levels of PGF2? were analyzed by radioimmunoassay (RIA). Differences among and within the groups were assessed using non-parametric statistical analysis. Ten periodontally healthy individuals served as controls. Results: All 3 groups showed statistically significant reductions in PBI and PI on day 10 and at 3 months (P <0.02), and in PD and CAL at 3 months (P <0.02, P <0.05, respectively). In the naproxen group, GT PGE2 levels exhibited a significant decrease (P <0.05). However, the decrease of GT PGE2 levels in the nimesulide group was insignificant (P >0.05), while a significant increase was observed in the placebo group (P <0.05) on day 10. Both the nimesulide and naproxen groups showed a significant decrease (P <0.05) in PGF2? level, while the placebo group showed a significant increase (P <0.05). Conclusions: Nimesulides, relatively selective COX-2 inhibitors, may have additional inhibitory effects on GT PGF2? levels in the first week following non-surgical periodontal treatment. However, nimesulide has an insignificant effect on reducing PGE2 levels in gingival tissue. The determination of GT levels of COX-1 and COX-2 enzymes as well as PGE2 and PGF2? in long-term studies may provide further support for the adjunctive use of selective COX-2 inhibitors in treatment of chronic periodontitis.en_US
dc.identifier.doi10.1902/jop.2003.74.1.57en_US
dc.identifier.endpage63en_US
dc.identifier.issn0022-3492
dc.identifier.issue1en_US
dc.identifier.pmid12593597en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2003.74.1.57
dc.identifier.urihttps://hdl.handle.net/11454/27913
dc.identifier.volume74en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdjunctive therapyen_US
dc.subjectGingiva/analysisen_US
dc.subjectNaproxenen_US
dc.subjectNimesulideen_US
dc.subjectPeriodontitis/therapyen_US
dc.subjectProstaglandin PGE2en_US
dc.subjectProstaglandin PGF2?en_US
dc.titleEffects of selective cyclooxygenase-2 inhibition on gingival tissue levels of prostaglandin E2 and prostaglandin F2? and clinical parameters of chronic periodontitisen_US
dc.typeArticleen_US

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