The Clinical and Cognitive Spectrum of Artery of Percheron Infarction: 1-Year Follow-Up

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dc.authoridKumral, Emre/0000-0002-3105-7734
dc.authorscopusid57223616502
dc.authorscopusid7003717249
dc.authorscopusid57263915500
dc.contributor.authorCetin, Fatma Ece
dc.contributor.authorKumral, Emre
dc.contributor.authorDere, Birgul
dc.date.accessioned2023-01-12T19:58:30Z
dc.date.available2023-01-12T19:58:30Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: Survivors of patients with artery of Percheron infarction (API) often have a prolonged and disabling form of cognitive impairment that remains insufficiently characterized. We aimed to examine the clinical and cognitive features of API in the short and long term after stroke. Methods: We reviewed 6400 patients with a first-ever stroke included in the Stroke Registry between 2011 and 2021. The diagnosis of API was based on clinical diagnosis and imaging confirmation. All patients underwent neuropsychological assessment at hospital stay and 1 year after stroke. A z-score of each patients' cognitive test point was calculated, and a z-score inferior to 2 was considered as pathological. Results: Of the 10 patients enrolled, all had cognitive impairment, consciousness, and behavioral disorders at stroke onset. Six patients had pure bilateral thalamic involvement while four had bilateral thalamic and rostral midbrain involvement. At 12 months, 50% of patients had global mental state scores 2 SD below the population mean (z-score mean +/- SD, -2.17 +/- 0.4). Most of the prefrontal cortex cognitive processes including executive functions such as planning and cognitive control (z-score mean +/- SD, -3.92 +/- 0.3), processing speed (-4.42 +/- 0.5), working memory (-3.97 +/- 0.3) were severely impaired at stroke onset. Especially in patients with thalamic and rostral midbrain involvement, deficiencies in executive function (z-score mean +/- SD, -2.60 +/- 0.4), processing speed (-2.22 +/- 0.5), working (-3.76 +/- 0.4), and episodic memory (-2.23 +/- 0.3) continued 12 months after stroke. Conclusions: The occlusion of the artery of Percheron results in severe behavioral and cognitive disorders in the short and long term after stroke.en_US
dc.identifier.doi10.1017/cjn.2021.212
dc.identifier.endpage780en_US
dc.identifier.issn0317-1671
dc.identifier.issn2057-0155
dc.identifier.issue6en_US
dc.identifier.pmid34505558en_US
dc.identifier.scopus2-s2.0-85115184270en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage774en_US
dc.identifier.urihttps://doi.org/10.1017/cjn.2021.212
dc.identifier.urihttps://hdl.handle.net/11454/76926
dc.identifier.volume49en_US
dc.identifier.wosWOS:000748333100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCanadian Journal of Neurological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThalamusen_US
dc.subjectRostral midbrainen_US
dc.subjectMRIen_US
dc.subjectArtery of Percheronen_US
dc.subjectThalamic Infarctsen_US
dc.subjectOcclusionen_US
dc.subjectMemoryen_US
dc.subjectStrokeen_US
dc.titleThe Clinical and Cognitive Spectrum of Artery of Percheron Infarction: 1-Year Follow-Upen_US
dc.typeArticleen_US

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