The (-174) G/C polymorphism in the interleukin-6 gene is associated with risk of papillary thyroid carcinoma in Turkish patients

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dc.contributor.authorOzgen, A. G.
dc.contributor.authorKaradeniz, M.
dc.contributor.authorErdogan, M.
dc.contributor.authorBerdeli, A.
dc.contributor.authorSaygili, F.
dc.contributor.authorYilmaz, C.
dc.date.accessioned2019-10-27T20:51:36Z
dc.date.available2019-10-27T20:51:36Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Interleukins and cytokines play an important role in the pathogenesis of many cancers. We aimed to evaluate the interleukin (IL)-6 gene polymorphisms in patients with papillary thyroid carcinoma (PTC) and control subjects. Material and methods: In this study, 42 patients with PTC and 340 healthy controls were included. Peripheral blood samples were taken from control group and patients, and blood samples were preserved at -80 C in tubes containing Na-EDTA. Results: We also found a statistically significant difference between patients with PTC and the control group with respect to IL-6 genotype (p<0.05). IL-6 gene polymorphism in patients with PTC patients did not reveal statistically significant difference between the 2 groups (size of tumor >1 cm and <1 cm), multicentricity, RET-PTC types and capsule invasion (p>0.05). We also did not find a statistically significant difference between patients with PTC and the control group with respect to IL-6-gene allele frequency (p>0.05). Discussion: Our data suggest that the IL-6 G-174 C polymorphism could play a role in thyroid cancer risk, but there is no effective role as a prognostic factor. (J. Endocrinol. Invest. 32: 491-494, 2009) (C) 2009, Editrice Kurtisen_US
dc.identifier.doi10.3275/6184en_US
dc.identifier.endpage494en_US
dc.identifier.issn1720-8386
dc.identifier.issue6en_US
dc.identifier.pmid19494710en_US
dc.identifier.startpage491en_US
dc.identifier.urihttps://doi.org/10.3275/6184
dc.identifier.urihttps://hdl.handle.net/11454/43130
dc.identifier.volume32en_US
dc.identifier.wosWOS:000271594800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject(-174) G/C polymorphisminen_US
dc.subjectinterleukin-6 geneen_US
dc.subjectpapillary thyroid carcinomaen_US
dc.titleThe (-174) G/C polymorphism in the interleukin-6 gene is associated with risk of papillary thyroid carcinoma in Turkish patientsen_US
dc.typeArticleen_US

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