Kalp Hızı Değişkenliği, Pulmoner Hipertansiyon Hastalarında Bir Prognostik Gösterge Olarak Kullanılabilir Mi? Tek Merkezli Bir Pilot Çalışma

Basit Öğe Kaydı
dc.authorscopusid57218910488
dc.authorscopusid57202353075
dc.authorscopusid57217126317
dc.authorscopusid7004155093
dc.authorscopusid6603063177
dc.authorscopusid14045359000
dc.authorscopusid6701848586
dc.contributor.authorMusayev, O.
dc.contributor.authorKayıkçıoğlu, M.
dc.contributor.authorShahbazova, S.
dc.contributor.authorNalbantgil, S.
dc.contributor.authorMoğulkoç, N.
dc.contributor.authorIbrahimov, F.
dc.contributor.authorKültürsay, H.
dc.date.accessioned2024-08-25T18:45:33Z
dc.date.available2024-08-25T18:45:33Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: Heart rate variability (HRV), which is defined as cyclic changes in sinus rate with time, is used as a measure of cardiac autonomic tone. Our aim was to determine the impact of HRV on short-term prognosis in pulmonary hypertension (PH). METHODS: We enrolled 64 PH patients and 69 healthy subjects (control group). Patients were evaluated by Holter-ECG, echocardiography, and laboratory tests. 24-h Holter-ECG monitoring was used for HRV. The development of adverse events (right heart failure, hospitalization, syncope, and death) during the 6-month follow-up was evaluated in PH group. RESULTS: PH group (39 ± 16 years, 37.5% males) comprised of 16 patients with idiopathic pulmonary arterial hypertension (PAH) (25%), 36 patients with PAH associated with congenital heart disease (56.3%), 3 PAH associated with connective tissue disease (4.7%), 1 with portopulmonary (1.6%), and 8 chronic thromboembolic PH (12.5%). The time-dependent (standard deviation of all NN intervals for a selected time period [SDNN], standard deviation of the 5-min mean R-R intervals tabulated over an entire day [SDANN], SDNN Index, and Triangular Index) and frequency-dependent HRV indices (low frequency, high-frequency power, and total power,) were significantly reduced in those with PH. Functional class was negatively associated with SDNN, SDANN, SDNN Index, and Triangular Index. Adverse events developed in 25% of the patients during the 6-month follow-up period (200 ± 92 days) (7 patients had right-heart failure, 5 syncope, 12 patients were hospitalized, and 9 had died). All the time and frequency-dependent indices significantly associated with adverse events. Mortality correlated with SDNN (rS = -0.354, P = 0.005), SDANN (rS = -0.368, P = 0.004), SDNN Index (rS = -0.257, P = 0.045), Triangular Index (rS = -0.310, P = 0.014), and VLF (rS = -0.265, P = 0.039). CONCLUSION: HRV is significantly depressed in patients with PH and is associated with the clinical status. HRV indices might predict clinical deterioration, adverse events, and mortality for 6 months. Non-invasive assessment of HRV through Holter-ECG may be a valuable and practical tool in risk stratification of patients with PH for short-term outcomes.en_US
dc.identifier.doi10.5543/tkda.2023.27078
dc.identifier.endpage463en_US
dc.identifier.issn1308-4488
dc.identifier.issue7en_US
dc.identifier.pmid37861265en_US
dc.identifier.scopus2-s2.0-85174865961en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage454en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2023.27078
dc.identifier.urihttps://hdl.handle.net/11454/101606
dc.identifier.volume51en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidiren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectambulatory electrocardiographyen_US
dc.subjectcomplicationen_US
dc.subjectfaintnessen_US
dc.subjectfemaleen_US
dc.subjectheart failureen_US
dc.subjectheart rateen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectphysiologyen_US
dc.subjectpilot studyen_US
dc.subjectprognosisen_US
dc.subjectpulmonary hypertensionen_US
dc.subjectElectrocardiography, Ambulatoryen_US
dc.subjectFemaleen_US
dc.subjectHeart Failureen_US
dc.subjectHeart Rateen_US
dc.subjectHumansen_US
dc.subjectHypertension, Pulmonaryen_US
dc.subjectMaleen_US
dc.subjectPilot Projectsen_US
dc.subjectPrognosisen_US
dc.subjectSyncopeen_US
dc.titleKalp Hızı Değişkenliği, Pulmoner Hipertansiyon Hastalarında Bir Prognostik Gösterge Olarak Kullanılabilir Mi? Tek Merkezli Bir Pilot Çalışmaen_US
dc.title.alternativeCould Heart Rate Variability Serve as a Prognostic Factor in Patients with Pulmonary Hypertension? A Single-center Pilot Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu