Clinicopathological and immunohistochemical analysis of sclerosing stromal tumours of the ovary

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dc.contributor.authorZekioglu, Osman
dc.contributor.authorOzdemir, N.
dc.contributor.authorTerek, C.
dc.contributor.authorOzsaran, A.
dc.contributor.authorDikmen, Y.
dc.date.accessioned2019-10-27T21:28:59Z
dc.date.available2019-10-27T21:28:59Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractSclerosing stromal tumours (SST) of the ovary are rare, benign tumours. SSTs are usually hormone inactive and tend to occur in the second and third decades of life. The most common clinical symptom is menstrual irregularity. Fourteen women diagnosed with SST of the ovary were included in this study. Tumour samples were collected, embedded in paraffin and stained with haematoxylin and eosin, periodic acid-Schiff (PAS), and PAS with digestion, as well as immunohistochemically for vimentin, smooth muscle actin, desmin, CD 99, inhibin-alpha and the oestrogen and progesterone receptor. The age of the patients ranged from 16 to 54 years (mean age 25.2 years). The tumours ranged in size from 6 to 21 cm (mean 10.5 cm). Macroscopically, eight tumours were solid and six were solid and cystic. All SSTs were well circumscribed with pseudolobule formation. Spindle-shaped fibroblast-like cells and vacuolated theca-like cells were prominent. Blood vessels exhibited a hemangiopericytomatous pattern and boomerang-like features. Immunohistochemical results were as follows: vimentin, 14/14 cases positive; smooth muscle actin, 14/14 cases positive; desmin, 14/14 cases positive; CD 99, 4/14 cases positive; inhibin-alpha, 14/14 cases positive; oestrogen receptor, 0/14 cases positive; progesterone receptor, 2/14 cases positive. The characteristic histopathological features we observed in our study are usually adequate for the diagnosis of SSTs. Although inhibin-alpha, CD 99 and desmin staining may be a useful and reliable tool for SST diagnosis in problematic cases, an immunohistochemical panel will not discriminate from other tumours in the sex cord-stromal group.en_US
dc.identifier.doi10.1007/s00404-010-1373-9en_US
dc.identifier.endpage676en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue6en_US
dc.identifier.pmid20135135en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage671en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-010-1373-9
dc.identifier.urihttps://hdl.handle.net/11454/45241
dc.identifier.volume282en_US
dc.identifier.wosWOS:000283938700015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvaryen_US
dc.subjectSclerosing stromal tumouren_US
dc.subjectCD 99en_US
dc.subjectInhibin alphaen_US
dc.subjectDesminen_US
dc.subjectSmooth muscle actinen_US
dc.titleClinicopathological and immunohistochemical analysis of sclerosing stromal tumours of the ovaryen_US
dc.typeArticleen_US

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