Chitosan modified graphite electrodes developed for electrochemical monitoring of interaction between daunorubicin and DNA

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dc.contributor.authorCongur G.
dc.contributor.authorEksin E.
dc.contributor.authorErdem A.
dc.date.accessioned2019-10-26T21:12:24Z
dc.date.available2019-10-26T21:12:24Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractChitosan (CHIT) modified single-use electrodes were developed for the first time in the present study and applied for electrochemical monitoring of anticancer drug-DNA interaction. Under this aim, pencil graphite electrode (PGE) was used as the biosensor platform and the modification of PGEs using biopolymer, CHIT was performed by passive adsorption process. Microscopic and electrochemical characterizations of CHIT modified PGEs were performed. An anticancer drug, Daunorubicin (DNR) was analyzed by using both PGEs and CHIT-PGEs. Moreover, the effect of CHIT modification on biosensor development upon to the sensitivity of voltammetric detection of DNR and DNA was also investigated. The interaction between DNA and DNR was then performed and accordingly, the voltammetric measurements were performed before/after interaction process by using differential pulse voltammetry (DPV) technique. © 2018en_US
dc.identifier.doi10.1016/j.sbsr.2018.100255
dc.identifier.issn2214-1804
dc.identifier.issn2214-1804en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.sbsr.2018.100255
dc.identifier.urihttps://hdl.handle.net/11454/15692
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSensing and Bio-Sensing Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnticancer drug-DNA interactionen_US
dc.subjectBiomaterial modified biosensoren_US
dc.subjectChitosan modified electrodeen_US
dc.subjectDaunorubicinen_US
dc.subjectDifferential pulse voltammetryen_US
dc.titleChitosan modified graphite electrodes developed for electrochemical monitoring of interaction between daunorubicin and DNAen_US
dc.typeArticleen_US

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