Chitosan modified graphite electrodes developed for electrochemical monitoring of interaction between daunorubicin and DNA
Küçük Resim Yok
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Chitosan (CHIT) modified single-use electrodes were developed for the first time in the present study and applied for electrochemical monitoring of anticancer drug-DNA interaction. Under this aim, pencil graphite electrode (PGE) was used as the biosensor platform and the modification of PGEs using biopolymer, CHIT was performed by passive adsorption process. Microscopic and electrochemical characterizations of CHIT modified PGEs were performed. An anticancer drug, Daunorubicin (DNR) was analyzed by using both PGEs and CHIT-PGEs. Moreover, the effect of CHIT modification on biosensor development upon to the sensitivity of voltammetric detection of DNR and DNA was also investigated. The interaction between DNA and DNR was then performed and accordingly, the voltammetric measurements were performed before/after interaction process by using differential pulse voltammetry (DPV) technique. © 2018
Açıklama
Anahtar Kelimeler
Anticancer drug-DNA interaction, Biomaterial modified biosensor, Chitosan modified electrode, Daunorubicin, Differential pulse voltammetry
Kaynak
Sensing and Bio-Sensing Research
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
22
