Venomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Turkiye

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dc.authoridDamm, Maik/0000-0003-0810-3699
dc.contributor.authorDamm, Maik
dc.contributor.authorKaris, Mert
dc.contributor.authorPetras, Daniel
dc.contributor.authorNalbantsoy, Ayse
dc.contributor.authorGocmen, Bayram
dc.contributor.authorSuessmuth, Roderich D.
dc.date.accessioned2024-08-31T07:50:38Z
dc.date.available2024-08-31T07:50:38Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractSnake venom variations are a crucial factor to understand the consequences of snakebite envenoming worldwide, and therefore it is important to know about toxin composition alterations between taxa. Palearctic vipers of the genera Vipera, Montivipera, Macrovipera, and Daboia have high medical impacts across the Old World. One hotspot for their occurrence and diversity is Turkiye, located on the border between continents, but many of their venoms remain still understudied. Here, we present the venom compositions of seven Turkish viper taxa. By complementary mass spectrometry-based bottom-up and top-down workflows, the venom profiles were investigated on proteomics and peptidomics level. This study includes the first venom descriptions of Vipera berus barani, Vipera darevskii, Montivipera bulgardaghica albizona, and Montivipera xanthina, as well as the first snake venomics profiles of Turkish Macrovipera lebetinus obtusa, and Daboia palaestinae, including an in-depth reanalysis of M. bulgardaghica bulgardaghica venom. Additionally, we identified the modular consensus sequence pEXW(PZ)1-2P(EI)/(KV)PPLE for bradykinin-potentiating peptides in viper venoms. For better insights into variations and potential impacts of medical significance, the venoms were compared against other Palearctic viper proteomes, including the first genus-wide Montivipera venom comparison. This will help the risk assessment of snakebite envenoming by these vipers and aid in predicting the venoms' pathophysiology and clinical treatments.en_US
dc.description.sponsorshipWe thank Tim Lu..ddecke, Ignazio Avella, and Lennart Schulte for critical feedback and reviewing the early manuscript. We dedicate this paper to the memory of Prof. Dr. Bayram Go..cmen, who lost his fight against cancer. He was an outstanding teacher, a good friend and colleague, and loved by his family.en_US
dc.identifier.doi10.1021/acs.jproteome.4c00171
dc.identifier.endpage3541en_US
dc.identifier.issn1535-3893
dc.identifier.issn1535-3907
dc.identifier.issue8en_US
dc.identifier.pmid38980134en_US
dc.identifier.scopus2-s2.0-85198393512en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3524en_US
dc.identifier.urihttps://doi.org/10.1021/acs.jproteome.4c00171
dc.identifier.urihttps://hdl.handle.net/11454/105311
dc.identifier.volume23en_US
dc.identifier.wosWOS:001265806500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofJournal of Proteome Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectVenomen_US
dc.subjectSnakebiteen_US
dc.subjectProteomicsen_US
dc.subjectPeptidomicsen_US
dc.subjectViperen_US
dc.titleVenomics and Peptidomics of Palearctic Vipers: A Clade-Wide Analysis of Seven Taxa of the Genera Vipera, Montivipera, Macrovipera, and Daboia across Turkiyeen_US
dc.typeArticleen_US

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