How Safe is the Use of Intrathecal Fluorescein? An Experimental Study

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dc.contributor.authorCamlar, Mahmut
dc.contributor.authorTurk, Caglar
dc.contributor.authorOltulu, Fatih
dc.contributor.authorOren, Merve
dc.contributor.authorBuhur, Aylin
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorOzer, Fusun
dc.contributor.authorGazioglu, Nurperi
dc.date.accessioned2019-10-27T09:47:37Z
dc.date.available2019-10-27T09:47:37Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractAIM: To investigate the effects of fluorescein-sodium on neural tissues. MATERIAL and METHODS: Twenty-one Wistar rats were randomly divided into three experimental groups: control (group 1) and fluorescein-sodium groups with different doses (groups 2 and 3). In the control group, craniectomy following with durotomy was performed with the help of a loupe microscope, and a dry sponge was overlayed to the brain tissue. In the study groups, the open dura was covered with a sponge soaked with 0.02 mg (group 2) and with 0.2 mg (group 3) fluorescein sodium following craniectomy. Three weeks postoperatively, rats were sacrificed for the histopathologic evaluations. RESULTS: Fluorescein-induced apoptosis occurs in a dose-dependent manner in rats' neurons. It was determined that neuron and neuroglial cell TUNEL staining was statistically different among the three groups (p<0.001). Our results indicated that fluorescein induces apoptosis, resulting in increased nuclear factor kappa beta (NF-kappa beta) expression in a dose-dependent manner. CONCLUSION: Fluorescein sodium is used frequently during surgery for CSF fistulas. However, information in the literature about its safety is insufficient. Our study holds promise for the development of new studies on the reliability of this agent.en_US
dc.identifier.doi10.5137/1019-5149.JTN.24085-18.3en_US
dc.identifier.endpage554en_US
dc.identifier.issn1019-5149
dc.identifier.issue4en_US
dc.identifier.pmid30806476en_US
dc.identifier.startpage549en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.24085-18.3
dc.identifier.urihttps://hdl.handle.net/11454/29426
dc.identifier.volume29en_US
dc.identifier.wosWOS:000473763100013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFluorescein-sodiumen_US
dc.subjectRhinorrheaen_US
dc.subjectNeurotoxic effecten_US
dc.subjectCSF fistulaen_US
dc.titleHow Safe is the Use of Intrathecal Fluorescein? An Experimental Studyen_US
dc.typeArticleen_US

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