Studies on Mefenamic Acid Microparticles: Formulation, In Vitro Release, and In Situ Studies in Rats

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dc.contributor.authorSevgi, Ferhan
dc.contributor.authorYurdasiper, Aysu
dc.contributor.authorKaynarsoy, Buket
dc.contributor.authorTurunc, Ezgi
dc.contributor.authorGueneri, Tamer
dc.contributor.authorYalcin, Ayfer
dc.date.accessioned2019-10-27T20:19:04Z
dc.date.available2019-10-27T20:19:04Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, we investigated the in vitro characteristics of mefenamic acid (MA) microparticles as well as their effects on DNA damage. MA-loaded chitosan and alginate beads were prepared by the ionotropic gelation process. Microsponges containing MA and Eudragit RS 100 were prepared by quasi-emulsion solvent diffusion method. The microparticles were characterized in terms of particle size, surface morphology, encapsulation efficiency, and in vitro release profiles. Most of the formulation variables manifested an influence on the physical characteristics of the microparticles at varying degrees. We also studied the effects of MA, MA-loaded microparticles, and three different polymers on rat brain cortex DNA damage. Our results showed that DNA damage was higher in MA-loaded Eudragit microsponges than MA-loaded biodegradable chitosan or alginate microparticles.en_US
dc.description.sponsorshipEge UniversityEge University [2003/ECZ/011]en_US
dc.description.sponsorshipThis study was supported by a research grant from Ege University (2003/ECZ/011). The authors thank Eczacibasi Pharmaceuticals Company, Istanbul, Turkey for kindly supplying the MA powder. We would like to thank Dr. Cengiz Tan from the Middle East Technical University (METU) for taking the scanning electron microphotographs. We would also like to thank Assoc. Prof. Dr. Zelihagul Degim from the Faculty of Pharmacy, Gazi University for her help for determining particle size.en_US
dc.identifier.doi10.1208/s12249-008-9183-0en_US
dc.identifier.endpage112en_US
dc.identifier.issn1530-9932
dc.identifier.issue1en_US
dc.identifier.pmid19184450en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://doi.org/10.1208/s12249-008-9183-0
dc.identifier.urihttps://hdl.handle.net/11454/41311
dc.identifier.volume10en_US
dc.identifier.wosWOS:000264842300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAaps Pharmscitechen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDNA damageen_US
dc.subjectkainic aciden_US
dc.subjectmefenamic aciden_US
dc.subjectmicroparticlesen_US
dc.titleStudies on Mefenamic Acid Microparticles: Formulation, In Vitro Release, and In Situ Studies in Ratsen_US
dc.typeArticleen_US

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