Preparation of technetium-99m labeled ibuprofen by direct route and technetium-99m tricarbonyl route: a comparison ofin vivobehaviors

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dc.contributor.authorDurkan, Kubra
dc.contributor.authorIchedef, Cigdem
dc.contributor.authorYurt Kilcar, Ayfer
dc.contributor.authorArici, Mesut
dc.contributor.authorUcar, Eser
dc.date.accessioned2020-12-01T12:01:02Z
dc.date.available2020-12-01T12:01:02Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the current study, ibuprofen (ibu) which is a non-steroidal anti-inflammatory drug (NSAID) was radiolabeled with(99m)Tc using two different methods: stannous chloride method (direct route) and technetium-99m tricarbonyl [Tc-99m(CO)(3)](+)route. Thus, it's aimed to investigate the radiolabeling potential of ibu for inflammation detection and to monitor if there is any difference inin vivodistribution depending on the radiolabeling route. Quality control studies of both radiolabeled ibu were performed by radiochromatographic methods (Thin Layer Liquid Radio Chromatography and High Performance Liquid Radio Chromatography). Radiolabeling yields of(99m)Tc-ibu and(99m)Tc(CO)(3)-ibu were determined as 99.05 +/- 0.83% and 91.79 +/- 3.30% (n = 5), respectively. Experimental lipophilicities of both radiolabeled ibu were determined. the biological behavior of both radiolabeled ibu was investigated in healthy Albino Wistar male rats byin vivobiodistribution studies. It was seen that both radiolabeled ibuprofen showed renal excretion while organ uptakes of(99m)Tc-ibu and(99m)Tc(CO)(3)-ibu differ against time.en_US
dc.description.sponsorshipEge University Scientific Research Project (BornovaIzmir, Turkey) [2011 NBE 010]en_US
dc.description.sponsorshipPresent study was financially supported by the Ege University Scientific Research Project numbered 2011 NBE 010 (BornovaIzmir, Turkey).en_US
dc.identifier.doi10.1080/03639045.2020.1776316en_US
dc.identifier.endpage1113en_US
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762
dc.identifier.issue7en_US
dc.identifier.pmid32479191en_US
dc.identifier.scopus2-s2.0-85087036506en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1108en_US
dc.identifier.urihttps://doi.org/10.1080/03639045.2020.1776316
dc.identifier.urihttps://hdl.handle.net/11454/62251
dc.identifier.volume46en_US
dc.identifier.wosWOS:000543645000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug Development and Industrial Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIbuprofenen_US
dc.subjectTechnetium-99men_US
dc.subjectradiolabelingen_US
dc.subjectin vivobiodistributionen_US
dc.subjectNSAIDen_US
dc.titlePreparation of technetium-99m labeled ibuprofen by direct route and technetium-99m tricarbonyl route: a comparison ofin vivobehaviorsen_US
dc.typeArticleen_US

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