Causes of high bone alkaline phosphatase

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dc.contributor.authorSarac, F.
dc.contributor.authorSaygili, F.
dc.date.accessioned2019-10-27T19:34:44Z
dc.date.available2019-10-27T19:34:44Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractSerum alkaline phosphatase (ALP) is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester. Many things may cause increases of ALP activity in serum, the most common being obstructive liver disease and metabolic bone disease. An increase of the liver or particularly the bone isoform (bone specfic ALP) in serum can provide valuable diagnostic information. Bone specific alkaline phosphatase isoenzyme is elevated as a result of increased osteoblastic activity. The highest total ALP values have been attributed to an increased bone isoenzyme level due to Paget disease or rickets/osteomalasia. The enzyme activity, which is localized in the plasma membrane of osteoblasts before extracellular release, correlates with the extent of the disease on skeletal surveys and with parameters of bone resorption. This isoenzymes is normally elevated in growing children and adults over the age of fifty. Causes of high bone ALP include bone growth, healing fracture, acromegaly, osteogenic sarcoma, or bone metastases, leukemia, myelofibrosis, and rarely myeloma; so ALP is used as a tumor marker. Hyperthyroidism, by its effects upon bone, may also elevate ALP We presented two patients have raised alkaline phosphatase. Isoenzyme studies confirmed its bony origin.en_US
dc.identifier.doi10.1080/13102818.2007.10817444
dc.identifier.endpage197en_US
dc.identifier.issn1310-2818
dc.identifier.issn1310-2818en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage194en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2007.10817444
dc.identifier.urihttps://hdl.handle.net/11454/39643
dc.identifier.volume21en_US
dc.identifier.wosWOS:000254704300014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDiagnosis Press Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbone specific alkaline phosphatasen_US
dc.subjectalkaline phosphataseen_US
dc.subjectosteomalaciaen_US
dc.subjectpaget's diseaseen_US
dc.titleCauses of high bone alkaline phosphataseen_US
dc.typeArticleen_US

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