Elevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: a new disorder of glucose tolerance

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dc.contributor.authorKabaroglu, Ceyda
dc.contributor.authorErsoy, Betul
dc.contributor.authorOnur, Ece
dc.contributor.authorOzhan, Bayram
dc.contributor.authorErdin, Soner
dc.contributor.authorVar, Ahmet
dc.contributor.authorBayindir, Oya
dc.contributor.authorDinc, Gonul
dc.date.accessioned2019-10-27T21:53:03Z
dc.date.available2019-10-27T21:53:03Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractWe observed glucose levels >140 mg/dL measured at 30 minutes (min) during an oral glucose tolerance test (OGTT) in some obese patients. We aimed to investigate the significance of this finding by comparing lipid profiles, insulin resistance indices, and systemic inflammatory mediators between obese adolescents with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and elevated glucose levels at 30 min. The study involved 80 obese (body mass index >95th percentile for age and sex) adolescents (48 female, 32 male) between 11 and 16 years of age. Depending on OGTT results, patients were divided into NGT and IGT groups. The third group was recruited from the NOT group as having glucose levels > 140 mg/dL at 30 minutes. Lipid profiles, [interleukin-6 (IL-6)], neopterin, and lipoprotein associated phospholipase A(2) (Lp-PLA(2))] were assessed. Neopterin and Lp-PLA(2) levels were significantly higher in obese adolescents with elevated glucose levels at 30 min. compared with those in both NGT and IGT groups (p=0.013, and 0.004, respectively). In these adolescents, IL-6 levels were significantly higher only than the NOT group (p=0.01). In logistic regression analysis, IL-6, neopterin and Lp-PLA(2) levels were detected to be related to high blood glucose levels at 30 min (OR 1.11, p = 0.01; OR 9.03, p=0.013; OR 1.01, p=0.004 respectively). Obese adolescents with elevated glucose levels at 30 min. demonstrated higher inflammatory mediators levels, which were atherosclerotic indicators, than obese adolescents with NGT and IGT. These results suggest that glucose levels >140 mg/dL measured at 30 min during an OGTT may be a new disorder of glucose tolerance in obesity.en_US
dc.identifier.doi10.1507/endocrj.EJ12-0079en_US
dc.identifier.endpage205en_US
dc.identifier.issn0918-8959
dc.identifier.issn1348-4540
dc.identifier.issue2en_US
dc.identifier.pmid23095208en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.1507/endocrj.EJ12-0079
dc.identifier.urihttps://hdl.handle.net/11454/47806
dc.identifier.volume60en_US
dc.identifier.wosWOS:000319027900011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapan Endocrine Socen_US
dc.relation.ispartofEndocrine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectObesityen_US
dc.subjectAdolescentsen_US
dc.subjectSystemic inflammatory mediatorsen_US
dc.subjectLp-PLA(2)en_US
dc.subjectInterleukin-6en_US
dc.titleElevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: a new disorder of glucose toleranceen_US
dc.typeArticleen_US

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