Bioconjugation and Applications of Amino Functional Fluorescence Polymers

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dc.contributor.authorGeyik, Caner
dc.contributor.authorGuler, Emine
dc.contributor.authorGumus, Zinar Pinar
dc.contributor.authorBarlas, Firat Baris
dc.contributor.authorAkbulut, Huseyin
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T11:10:23Z
dc.date.available2019-10-27T11:10:23Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractSynthesis and novel applications of biofunctional polymers for diagnosis and therapy are promising area involving various research domains. Herein, three fluorescent polymers, poly(p-phenylene-co-thiophene), poly(p-phenylene), and polythiophene with amino groups (PPT-NH2, PPP-NH2, and PT-NH2, respectively) are synthesized and investigated for cancer cell targeted imaging, drug delivery, and radiotherapy. Polymers are conjugated to anti-HER2 antibody for targeted imaging studies in nontoxic concentrations. Three cell lines (A549, Vero, and HeLa) with different expression levels of HER2 are used. In a model of HER2 expressing cell line (A549), radiotherapy experiments are carried out and results show that all three polymers increase the efficacy of radiotherapy. This effect is even more increased when conjugated to anti-HER2. In the second part of this work, one of the selected polymers (PT-NH2) is conjugated with a drug model; methotrexate via pH responsive hydrazone linkage and a drug carrier property of PT-NH2 is demonstrated on neuroblastoma (SH-SY5Y) cell model. Our results indicate that, PPT-NH2, PPP-NH2, and PT-NH2 have a great potential as biomaterials for various bioapplications in cancer research.en_US
dc.identifier.doi10.1002/mabi.201600232en_US
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.issue3en_US
dc.identifier.pmid27689764en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/mabi.201600232
dc.identifier.urihttps://hdl.handle.net/11454/32388
dc.identifier.volume17en_US
dc.identifier.wosWOS:000397503200004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofMacromolecular Bioscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbioconjugationen_US
dc.subjectbiofunctional polymersen_US
dc.subjectcell imagingen_US
dc.subjectdrug releaseen_US
dc.subjectfluorescent polymersen_US
dc.titleBioconjugation and Applications of Amino Functional Fluorescence Polymersen_US
dc.typeArticleen_US

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