Application of Green Gold Nanoparticles in Cancer Therapy and Diagnosis

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dc.authoridBilal, Muhammad/0000-0001-5388-3183
dc.authoridZafar, Muhammad Nadeem/0000-0002-2109-7601
dc.authoridSargazi, Saman/0000-0002-2255-5977
dc.authoridDiez Pascual, Ana Maria/0000-0001-7405-2354
dc.authoridHassanisaadi, Mohadeseh/0000-0002-5626-6583
dc.authoridER ZEYBEKLER, Simge/0000-0002-5814-0618
dc.authorscopusid57201953828
dc.authorscopusid57225053474
dc.authorscopusid57222095969
dc.authorscopusid36599143100
dc.authorscopusid57223935989
dc.authorscopusid55584792053
dc.authorscopusid6506667731
dc.authorwosidBilal, Muhammad/AAH-6461-2020
dc.authorwosidER, Simge/HGU-2032-2022
dc.authorwosidSargazi, Saman/Y-7793-2019
dc.authorwosidZafar, Muhammad Nadeem/AAA-1853-2020
dc.contributor.authorSargazi, Saman
dc.contributor.authorLaraib, Ushna
dc.contributor.authorEr, Simge
dc.contributor.authorRahdar, Abbas
dc.contributor.authorHassanisaadi, Mohadeseh
dc.contributor.authorZafar, Muhammad Nadeem
dc.contributor.authorDiez-Pascual, Ana M.
dc.date.accessioned2023-01-12T20:15:43Z
dc.date.available2023-01-12T20:15:43Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractNanoparticles are currently used for cancer theranostics in the clinical field. Among nanoparticles, gold nanoparticles (AuNPs) attract much attention due to their usability and high performance in imaging techniques. The wide availability of biological precursors used in plant-based synthesized AuNPs allows for the development of large-scale production in a greener manner. Conventional cancer therapies, such as surgery and chemotherapy, have significant limitations and frequently fail to produce satisfying results. AuNPs have a prolonged circulation time, allow easy modification with ligands detected via cancer cell surface receptors, and increase uptake through receptor-mediated endocytosis. To exploit these unique features, studies have been carried out on the use of AuNPs as contrast agents for X-ray-based imaging techniques (i.e., computed tomography). As nanocarriers, AuNPs synthesized by nontoxic and biocompatible plants to deliver therapeutic biomolecules could be a significant stride forward in the effective treatment of various cancers. Fluorescent-plant-based markers, including AuNPs, fabricated using Medicago sativa, Olax Scandens, H. ambavilla, and H. lanceolatum, have been used in detecting cancers. Moreover, green synthesized AuNPs using various extracts have been applied for the treatment of different types of solid tumors. However, the cytotoxicity of AuNPs primarily depends on their size, surface reactivity, and surface area. In this review, the benefits of plant-based materials in cancer therapy are firstly explained. Then, considering the valuable position of AuNPs in medicine, the application of AuNPs in cancer therapy and detection is highlighted with an emphasis on limitations faced by the application of such NPs in drug delivery platforms.en_US
dc.description.sponsorshipCommunity of Madrid; University of Alcala [EPU-INV/2020/012]en_US
dc.description.sponsorshipFinancial support from the Community of Madrid within the framework of the Multiyear Agreement with the University of Alcala for Stimulus to Excellence for Permanent University Professors, Ref. EPU-INV/2020/012 is gratefully acknowledged.en_US
dc.identifier.doi10.3390/nano12071102
dc.identifier.issn2079-4991
dc.identifier.issue7en_US
dc.identifier.pmid35407220en_US
dc.identifier.scopus2-s2.0-85127063125en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/nano12071102
dc.identifier.urihttps://hdl.handle.net/11454/78556
dc.identifier.volume12en_US
dc.identifier.wosWOS:000781717000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofNanomaterialsen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectbiosynthesisen_US
dc.subjectgold nanoparticlesen_US
dc.subjectgreen synthesisen_US
dc.subjectsurface plasmon resonanceen_US
dc.subjectleaf extracten_US
dc.subjecttoxicityen_US
dc.subjectDrug-Deliveryen_US
dc.subjectAnticancer Activityen_US
dc.subjectLeaf Extracten_US
dc.subjectIn-Vitroen_US
dc.subjectSilver Nanoparticlesen_US
dc.subjectContrast Agenten_US
dc.subjectPhotothermal Therapyen_US
dc.subjectComputed-Tomographyen_US
dc.subjectOxide Nanoparticlesen_US
dc.subjectCell-Lineen_US
dc.titleApplication of Green Gold Nanoparticles in Cancer Therapy and Diagnosisen_US
dc.typeReviewen_US

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