Correlation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients

Basit Öğe Kaydı
dc.contributor.authorEker, Cagdas
dc.contributor.authorKitis, Omer
dc.contributor.authorTaneli, Fatma
dc.contributor.authorEker, Ozlem Donat
dc.contributor.authorOzan, Erol
dc.contributor.authorYucel, Kaan
dc.contributor.authorCoburn, Kerry
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2019-10-27T21:14:34Z
dc.date.available2019-10-27T21:14:34Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractThe hippocampus seems to be affected in MDD, and brain-derived neurotrophic factor (BDNF) has positive effects on neurogenesis within the hippocampus. Although there are inconsistencies among study results, a smaller hippocampal volume in depressed patients is thought to be related to the pathophysiology of the disease. We looked at the correlation between serum BDNF (sBDNF) levels and hippocampal volumes (HCV) of first-episode MDD patients (18 female, 7 male; mean age = 32.1 +/- A 9.3) and healthy controls (17 female, 5 male; mean age = 29.7 +/- A 6.4). Region of interest analysis was conducted on the images acquired via MRI. sBDNF levels and HCV correlated only in the MDD group (right: r = 0.46, P = 0.02; left: r = 0.47, P = 0.02); however, HCV did not differ between MDD patients and healthy controls (right: F = 2.45, df = 1.46, P > 0.05; left: F = 0.05, df = 1.46, P > 0.05). BDNF may be a factor underlying HCV differences between MDD and healthy control subjects, which become apparent as severe and multiple episodes are experienced.en_US
dc.description.sponsorshipIhsan Dogramaci Foundation; Izmir Psychiatric Associationen_US
dc.description.sponsorshipAuthors would like to thank to Selami Karaaslan, MD for his help to recruit subjects. This study is a part of SoCAT Project supported by Ihsan Dogramaci Foundation and was partially supported by Huray Fidaner Research Award of Izmir Psychiatric Association to corresponding author (ASG); the organizations mentioned above had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.en_US
dc.identifier.doi10.1007/s00406-010-0110-5en_US
dc.identifier.endpage533en_US
dc.identifier.issn0940-1334
dc.identifier.issue7en_US
dc.identifier.pmid20306200en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage527en_US
dc.identifier.urihttps://doi.org/10.1007/s00406-010-0110-5
dc.identifier.urihttps://hdl.handle.net/11454/43405
dc.identifier.volume260en_US
dc.identifier.wosWOS:000282872700004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBDNFen_US
dc.subjectHippocampusen_US
dc.subjectDepressionen_US
dc.subjectMRIen_US
dc.subjectVolumeen_US
dc.titleCorrelation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu