Vitamin D status of exclusively breastfed 4-month-old infants supplemented during different seasons

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dc.contributor.authorHalicioglu O.
dc.contributor.authorSutcuoglu S.
dc.contributor.authorKoc F.
dc.contributor.authorYildiz O.
dc.contributor.authorAkman S.A.
dc.contributor.authorAksit S.
dc.date.accessioned2019-10-27T08:33:19Z
dc.date.available2019-10-27T08:33:19Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: To examine the vitamin D status of 4-month-old exclusively breastfed infants supplemented with 400 IU daily of vitamin D and to determine whether there was any seasonal variation in serum 25-hydroxyvitamin D (25(OH)D) levels of infants. METHODS: In this cross-sectional study, serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, and 25(OH)D levels of 143 exclusively breastfed 4-month-old infants supplemented daily with 400 IU of vitamin D were measured in a temperate latitude, Izmir, Turkey, between May 2008 and April 2009. A questionnaire on demographic characteristics of infants and mothers, vitamin D supplementation of infants after birth, mothers' multivitamin supplementation, dressing habits, and consumption of dairy products during pregnancy was used. RESULTS: Vitamin D deficiency (?50 nmol/L) and insufficiency (51-74 nmol/L) were determined in 40 (28%) and 55 (38.5%) infants, respectively. During winter days, serum 25(OH)D levels were <20 ng/mL in 45.4% of infants and <10 ng/mL in 10.6% of infants. Season of blood sampling, compliance of vitamin D supplementation, maternal education level, and consumption of dairy products were highly predictive of serum 25(OH)D levels in multiple linear regression analysis (P < .05). The use of the Pearson correlation test found a statistically significant negative correlation between 25(OH)D and parathyroid hormone levels (r = -0.419, P < .001). CONCLUSIONS: Despite supplementation with 400 IU of vitamin D daily, the rate of vitamin D deficiency was worryingly high in 4-month-old exclusively breastfed infants living in Izmir, Turkey. So, additional studies are needed to clarify optimal amount of vitamin D supplementation to the infants, especially during winter days. Copyright © 2012 by the American Academy of Pediatrics.en_US
dc.identifier.doi10.1542/peds.2012-0017en_US
dc.identifier.endpagee927en_US
dc.identifier.issn0031-4005
dc.identifier.issue4en_US
dc.identifier.pmid23008460en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpagee921en_US
dc.identifier.urihttps://doi.org/10.1542/peds.2012-0017
dc.identifier.urihttps://hdl.handle.net/11454/26731
dc.identifier.volume130en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmerican Academy of Pediatricsen_US
dc.relation.ispartofPediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreastfeedingen_US
dc.subjectInfanten_US
dc.subjectSeasonal variationen_US
dc.subjectVitamin Den_US
dc.titleVitamin D status of exclusively breastfed 4-month-old infants supplemented during different seasonsen_US
dc.typeArticleen_US

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