Serial Intravesical Pressure Measurements Can Predict the Presence and the Severity of Necrotizing Enterocolitis

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dc.contributor.authorTanriverdi, Sema
dc.contributor.authorKoroglu, Ozge
dc.contributor.authorUygur, Ozgun
dc.contributor.authorCelik, Ahmet
dc.contributor.authorDulger, Fatma
dc.contributor.authorYalaz, Mehmet
dc.contributor.authorAkisu, Mete
dc.contributor.authorKultursay, Nilgun
dc.date.accessioned2019-10-27T21:52:03Z
dc.date.available2019-10-27T21:52:03Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and Aims Necrotizing enterocolitis (NEC) which is accompanied with gastrointestinal ulceration and necrosis is one of the most important problems of preterm infants in neonatal intensive care unit (NICU). Increased intra-abdominal pressure (IAP) is detected among most of the pediatric patients hospitalized in intensive care unit and undergoing surgery or trauma. This pathology, namely, abdominal compartment syndrome, causes ischemia and hypoperfusion of abdominal organs. Recently, the effect of increased IAP on NEC is under focus and this increase is thought to be related with the onset of NEC by leading to intestinal ischemia and necrosis. In this study, we aimed to investigate if serial intravesical pressure (IVP) measurements as an indirect indicator of IAP may help to early diagnosis in NEC and to decision for surgery besides to predict the mortality of NEC. Material and Method A total number of 61 preterm infants with a birth weight of <= 1,500 g hospitalized in NICU were included to the study. IVP values were measured by the same nurse twice daily during their hospitalization through urinary catheter. The IVP values of the preterm infants with and without NEC were compared. Results Totally 61 premature infants included in the study were grouped as follows: group 0, the control group without NEC (n = 38); group 1, medically treated NEC patients (n = 14); and group 2, NEC patients undergoing surgery (n = 9). The median IVP measurements of group 0 were lower than the other groups (p = 0.001). No statistically significant difference in IVP measurements was detected between group 1 and group 2 (p = 0.155). A 10% of increase in IVP measurement was significant in predicting the development of NEC with consecutive serial measurements. The mean IVP measurements were higher in infants with NEC who died during their follow-up at NICU compared with NEC patients who survived (p = 0.043). Conclusion Serial IVP measurements may help for early diagnosis and surgery decision of NEC and high IVP levels also may predict mortality in cases with NEC.en_US
dc.identifier.doi10.1055/s-0032-1329706en_US
dc.identifier.endpage248en_US
dc.identifier.issn0939-7248
dc.identifier.issn1439-359X
dc.identifier.issue3en_US
dc.identifier.pmid23165520en_US
dc.identifier.startpage243en_US
dc.identifier.urihttps://doi.org/10.1055/s-0032-1329706
dc.identifier.urihttps://hdl.handle.net/11454/47468
dc.identifier.volume23en_US
dc.identifier.wosWOS:000320922900012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofEuropean Journal of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnecrotizing enterocolitisen_US
dc.subjectintra-abdominal pressureen_US
dc.subjectintravesical pressureen_US
dc.subjectnewbornen_US
dc.titleSerial Intravesical Pressure Measurements Can Predict the Presence and the Severity of Necrotizing Enterocolitisen_US
dc.typeArticleen_US

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