Ballard and new ballard scoring systems in the assessment of gestational age in preterm infants [Prematüre bebeklerde patent duktus arteriozusun tedavisinde enteral ibuprofen ve indometazinin etkinligi ve güvenilirligi]
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study was designed to investigate the efficacy and safety of enteral ibuprofen for the treatment of patent ductus arteriosus (PDA) and to compare it with enteral indomethacin. Twenty-three premature infants with gestational ages of less than 35 weeks with echocardiographically confirmed PDA were randomly assigned to receive either enteral indomethacin (3 × 0.2 mg/kg at 12 hour intervals) or enteral ibuprofen (1 × 10 mg/kg, followed by 5 mg/kg 24 and 48 hours later). PDA closed in eight of 11 patients (72%) from the indomethacin group and in 10 of 12 (83%) from the ibuprofen group in the first treatment. Five patients (three from indomethacin group, two from ibuprofen group) required a second treatment with the same drug. Ultimately, PDA closed in nine preterm infants from the indomethacin group (81%) and in 10 preterm infants from the ibuprofen group (83%). Ibuprofen patients had a better urinary output compared with the indomethacin group, an ibuprofen treatment was not associated with significant side effects. As a result, ibuprofen treatment seems to be as efficient as indomethacin in closing PDA in preterm infants, with fewer renal side effects.
Açıklama
Anahtar Kelimeler
Ibuprofen, Indomethacin, Newborn, Patent ductus arteriosus
Kaynak
Cocuk Sagligi ve Hastaliklari Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
44
Sayı
1
