A Multicenter Study of Self-Limited Epilepsy With Centrotemporal Spikes: Effectiveness of Antiseizure Medication With Respect to Spike-Wave Index

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dc.authoridSERDAROGLU, ESRA/0000-0001-9925-0859
dc.authoridDilber, Beril/0000-0002-7633-0060
dc.contributor.authorDilber, Beril
dc.contributor.authorSerdaroglu, Esra
dc.contributor.authorKanmaz, Seda
dc.contributor.authorKilic, Betuel
dc.contributor.authorIpek, Rojan
dc.contributor.authorMenderes, Deniz Kargin
dc.contributor.authorYildiz, Nihal
dc.date.accessioned2024-08-31T07:50:18Z
dc.date.available2024-08-31T07:50:18Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: There is no certain validated electroencephalographic (EEG) parameters for outcome prediction in children with self-limited epilepsy with centrotemporal spikes. To assess the effectiveness of antiseizure medication (ASM) for seizure outcome with respect to the spike-wave index (SWI) on serial EEG recordings. Methods: In this multicenter study, the study cohort consisted of 604 children with self-limited epilepsy with centrotemporal spikes. A data set of epilepsy centers follow-up between 2010 and 2022. The cohort was divided into 4 groups as those receiving 3 different monotherapy (carbamazepine [CBZ]/valproic acid [VPA]/levetiracetam [LEV]) and dual therapy. SWI analysis was performed with the percent of spikes in the 2-minute epoch in the 5th 6th minutes of the nonrapid eye movement sleep EEG record. The study group were also categorized according to seizure burden with seizure frequency (I) >2 seizures and (II) >5 seizures. Seizure outcome was evaluated based on the reduction in seizure frequency over 6-month periods: (1) 50% reduction and (2) seizure-free (complete response). Results: ASM monotherapy was achieved in 74.5% children with VPA, CBZ, and LEV with similar rates of 85.8%, 85.7%, and 77.9%. Dual therapy was need in the 25.5% of children with SeLECT. More dual therapy was administered in children aged below 5 years with a rate of 46.2%. Earlier seizure-free achievement time was seen in children with LEV monotherapy with more complete-response rate (86.7%) compared the VPA and CBZ. Conclusions: We also determined that the children on dual therapy had more SWI clearance in the subsequent EEG recordings. The ROC curve analyses were performed to predict initial drug selection with using the SWI% might be used for the prediction of ASM type and drug selection in children. (c) 2023 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pediatrneurol.2023.12.014
dc.identifier.endpage86en_US
dc.identifier.issn0887-8994
dc.identifier.issn1873-5150
dc.identifier.pmid38237317en_US
dc.identifier.scopus2-s2.0-85182554518en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1016/j.pediatrneurol.2023.12.014
dc.identifier.urihttps://hdl.handle.net/11454/105191
dc.identifier.volume152en_US
dc.identifier.wosWOS:001164920000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectSelf Limited Epilepsy With Centrotemporalen_US
dc.subjectSpikesen_US
dc.subjectAntiseizure Medicationen_US
dc.subjectSpike-Wave Indexen_US
dc.subjectPediatricsen_US
dc.titleA Multicenter Study of Self-Limited Epilepsy With Centrotemporal Spikes: Effectiveness of Antiseizure Medication With Respect to Spike-Wave Indexen_US
dc.typeArticleen_US

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