Investigations on the anti-ulcerogenic activity of Sideritis caesarea H. Duman, Aytac & Baser

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dc.contributor.authorGunbatan, Tugba
dc.contributor.authorGurbuz, Ilhan
dc.contributor.authorBedir, Erdal
dc.contributor.authorOzkan, Ayse Mine Gencler
dc.contributor.authorOzcinar, Ozge
dc.date.accessioned2020-12-01T11:58:35Z
dc.date.available2020-12-01T11:58:35Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractEthnopharmacological relevance: Aerial parts of Sideritis caesarea H. Duman, Aytac & Baser are used for complaints such as stomach-aches, and intestinal spasms as traditional medicine in Kayseri, Turkey. Aim of study: To investigate the anti-ulcerogenic activity by using bioassay guided fractionation technique (BAGF) and to identify the compound(s) that are responsible for anti-ulcerogenic activity through ethanol-induced anti-ulcerogenic activity model in vivo. Materials and methods: Liquid-liquid partition and then different chromatographic techniques were utilized for the BAGF of the ethanol (80%) extract of the aerial parts of Sideritis caesarea. Ethanol-induced gastric ulcer method on rats was employed for the determination of the anti-ulcerogenic activity, and the ulcer index was also calculated for anti-ulcerogenic activity detection. Results: the ethanol (80%) extract of S. caesarea showed statistically potent anti-ulcerogenic activity (95.9% ulcer inhibition, p < 0.001). Among the liquid-liquid fractions, strongest anti-ulcerogenic activity was observed with the ethyl acetate fraction (91.4% inhibition, p< 0.001) and therefore BAGF studies were proceeded with the ethyl acetate fraction. Two anti-ulcerogenic flavonoids {4'-O-methylhypolaetin-7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]- 6 ''-O-acetyl-beta-D-glucopyranoside and isoscutellarein-7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-6 ''-O-acetyl-beta-D-glucopyranoside} were isolated from this fraction together with a sesquiterpene glycoside [(2E,6E)-2,6,10-trimethyl-2,6,11-dodecatriene-1,10-diol-1-O-beta-D-glucopyranoside] and two additional flavonoids {4'-O-methylhypolaetin-7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside and isoscutellarein- 7-O-[6'''-O-acetyl-beta-D-allopyranosyl-(1 -> 2)]-beta-D-glucopyranoside}. Conclusions: Traditional use of S. caesarea in the treatment of stomach-aches was supported by this study and four flavonoids were isolated by using BAGF method and two of them were determined to have significant antiulcerogenic activity. Additionally, (2E,6E)-2,6,10-trimethyl-2,6,11-dodecatriene-1,10-diol-1-O-beta-D-glucopyranoside was obtained from a Sideritis genus for the first time.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey-TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG-112S581]en_US
dc.description.sponsorshipThis study was financially supported by "The Scientific and Technological Research Council of Turkey-TUBITAK" (project number: TBAG-112S581).en_US
dc.identifier.doi10.1016/j.jep.2020.112920en_US
dc.identifier.issn0378-8741
dc.identifier.issn1872-7573
dc.identifier.pmid32360801en_US
dc.identifier.scopus2-s2.0-85084239008en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jep.2020.112920
dc.identifier.urihttps://hdl.handle.net/11454/62060
dc.identifier.volume258en_US
dc.identifier.wosWOS:000536887800018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofJournal of Ethnopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSideritis caesareaen_US
dc.subjectAnti-Ulcerogenic activityen_US
dc.subjectBioassay-guided fractionationen_US
dc.subjectPeptic ulceren_US
dc.subjectFolk medicineen_US
dc.titleInvestigations on the anti-ulcerogenic activity of Sideritis caesarea H. Duman, Aytac & Baseren_US
dc.typeArticleen_US

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