Serum and urinary nitric oxide in Type 2 diabetes with or without microalbuminuria: Relation to glomerular hyperfiltration

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dc.contributor.authorApakkan Aksun S.
dc.contributor.authorÖzmen B.
dc.contributor.authorÖzmen D.
dc.contributor.authorParildar Z.
dc.contributor.authorŞenol B.
dc.contributor.authorHabif S.
dc.contributor.authorMutaf I.
dc.contributor.authorTurgan N.
dc.contributor.authorBayindir O.
dc.date.accessioned2019-10-27T08:59:49Z
dc.date.available2019-10-27T08:59:49Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: Glomerular hyperfiltration is considered as one of the pathophysiological mechanisms for the development of diabetic nephropathy. Oxidative stress is enhanced in patients with diabetes mellitus. Reportedly, nitric oxide (NO) might be involved in the pathogenesis of hyperfiltration. We investigated the relationship between hyperfiltration and NO system, and malondialdehyde (MDA) levels in Type 2 diabetics with/without microalbuminuria. Methods: In 39 microalbuminuric, 29 normoalbuminuric Type 2 diabetic patients and 32 healthy controls, serum creatinine, nitrite, nitrate, urinary microalbumin, nitrite, nitrate, plasma MDA and estimated glomerular filtration rate (EGFR) values, calculated according to the Cockcroft and Gault formula, were recorded. Results: Serum and urine NO levels were higher in both microalbuminurics and normoalbuminurics than controls. There were no significant differences in EGFR between groups. However, hyperfiltration was determined in 31% of normoalbuminurics and 20% of microalbuminurics. Serum and urine NO levels were higher in patients with hyperfiltration. Plasma MDA levels were significantly elevated in both microalbuminurics and normoalbuminurics when compared with controls. Serum glucose and microalbuminuria were positively correlated in microalbuminuric diabetics. Serum NO levels were also positively correlated with EGFR in both normoalbuminurics and microalbuminurics. HbA1c levels were positively correlated with both urinary albumin excretion and plasma MDA levels in normoalbuminuric diabetics. Conclusion: Hyperglycemia is associated with an increased NO biosynthesis and lipid peroxidation. Increased oxidative stress may contribute to the high NO levels in Type 2 diabetes. Furthermore, the high NO levels may lead to hyperfiltration and hyperperfusion, which in turn leads to an increase in urinary albumin excretion and thus causes progression of nephropathy in early Type 2 diabetes. © 2003 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/S1056-8727(02)00196-4en_US
dc.identifier.endpage348en_US
dc.identifier.issn1056-8727
dc.identifier.issue6en_US
dc.identifier.pmid14583179en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage343en_US
dc.identifier.urihttps://doi.org/10.1016/S1056-8727(02)00196-4
dc.identifier.urihttps://hdl.handle.net/11454/27916
dc.identifier.volume17en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofJournal of Diabetes and its Complicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic nephropathyen_US
dc.subjectGlomerular hyperfiltrationen_US
dc.subjectLipid peroxidationen_US
dc.subjectMicroalbuminuriaen_US
dc.subjectNitric oxideen_US
dc.titleSerum and urinary nitric oxide in Type 2 diabetes with or without microalbuminuria: Relation to glomerular hyperfiltrationen_US
dc.typeArticleen_US

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