Cytotoxic effects of silver nanoparticles synthesized using Asphodelus aestivus Brot. aqueous extract

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dc.authorscopusid57195953961
dc.authorscopusid36113162500
dc.authorscopusid57969192300
dc.authorscopusid57191416192
dc.authorscopusid56497855800
dc.authorscopusid54889084200
dc.authorscopusid6603599022
dc.contributor.authorTastan, Pelin
dc.contributor.authorFafal, Tugce
dc.contributor.authorTuezuen, Burcu Suemer
dc.contributor.authorOzmen Yelken, Besra
dc.contributor.authorKayabasi, Cagla
dc.contributor.authorYilmaz Susluer, Sunde
dc.contributor.authorGunduz, Cumhur
dc.date.accessioned2024-08-25T18:51:43Z
dc.date.available2024-08-25T18:51:43Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of the study is to examine the cytotoxic, apoptotic effects and gene expressions of Asphodelus aestivus water extract (ASP) and silver nanoparticles (AgNPS) on decided cancer lines. Breast cancer cell lines MCF-7 and MDA-231; melanoma cancer lines MEWO and CHL-1; fibroblast cancer lines WI-38 and HEL 299 were selected for biological activities. xCELLigence system was used for cytotoxicity. Annexin V-EG FP Apoptosis detection kit was used for apoptosis and gene expressions were assessed by real time online RT-PCR by using cancer cell lines Qiagen kits. AgNPS showed significant cytotoxicity in all cell lines. The most prominent apoptosis was determined in MCF-7 cell line for AgNPS. It has been observed that the most important progress in gene expression, the suppression capacity of MUC1-C, a breast cancer-associated oncoprotein, is greatly increased by nanoparticle formation. In addition, cells that were not affected at all in MDA-MB-231 breast cancer oncoprotein started to suppress with nanoparticles. In conclusion, it was determined that silver nanoparticles increased the effect especially in breast cancer cell lines and could be considered for use.en_US
dc.description.sponsorshipTUBITAK [SBAG-114S730]; FABAL (Ege University, Faculty of Pharmacy Pharmaceutical Sciences Research Centre); Izmir Institute of Technology, Center for Materials Researchen_US
dc.description.sponsorshipThis research was supported by TUBITAK (project number SBAG-114S730) . We are thankful to FABAL (Ege University, Faculty of Pharmacy Pharmaceutical Sciences Research Centre) and Izmir Institute of Technology, Center for Materials Research.en_US
dc.identifier.doi10.29228/jrp.413
dc.identifier.endpage1251en_US
dc.identifier.issn2630-6344
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85161585377en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1242en_US
dc.identifier.trdizinid1179514en_US
dc.identifier.urihttps://doi.org/10.29228/jrp.413
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1179514
dc.identifier.urihttps://hdl.handle.net/11454/102691
dc.identifier.volume27en_US
dc.identifier.wosWOS:001011434600021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectGreen synthesisen_US
dc.subjectapoptosisen_US
dc.subjectcanceren_US
dc.subjectmelanomaen_US
dc.subjectcancer cell linesen_US
dc.subjectsilver nanoparticlesen_US
dc.subjectAntioxidant Activityen_US
dc.subjectLeaf Extracten_US
dc.subjectAntibacterialen_US
dc.subjectTwisten_US
dc.titleCytotoxic effects of silver nanoparticles synthesized using Asphodelus aestivus Brot. aqueous extracten_US
dc.typeArticleen_US

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