Value of cervical phosphorylated insulinlike growth factor binding protein-1 in the prediction of preterm labor

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dc.contributor.authorAkercan, F
dc.contributor.authorKazandi, M
dc.contributor.authorSendag, F
dc.contributor.authorCirpan, T
dc.contributor.authorMgoyi, L
dc.contributor.authorTerek, MC
dc.contributor.authorSagol, S
dc.date.accessioned2019-10-27T19:03:59Z
dc.date.available2019-10-27T19:03:59Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE: To determine the value of cervical phosphorylated insulin-like growth factor binding protein-1 (IGFBP-1) in the prediction of preterm labor. STUDY DESIGN: In this prospective study, 77 pregnant women, gestational age 24-36 weeks, were enrolled in the study. Twenty women with completely healthy pregnancies formed the control group. Fifty-seven women with signs and symptoms of preterm labor formed the study group. Phosphorylated IGFBP-1 in cervical secretions was assessed in all patients by using a qualitative, immunochromatographic, I-step dipstick test. Cervical length was measured by transvaginal sonography. RESULTS: The IGFBP-1 test was negative in all patients in the control group (n = 20), and all of them delivered after 37 weeks, while the test was positive in 15 of 45 (33.3%) patients in the study group. The correlation between cervical length and gestational age at the time of delivery in patients with a positive phosphorylated IGFBP-1 test (n = 15) was significant (r = .553, P = .03). The sensitivity., specificity, positive predictive value and negative predictive value for the phosphorylated IGFBP-1 test were 78%, 87%, 73% and 90%, respectively. CONCLUSION: Use of a I-step dipstick test for detecting phosphorylated IGFBP-1 in cervical secretions is of value in the prediction of preterm labor. The high negative predictive value of the test may be useful in avoiding unnecessary medical interventions.en_US
dc.identifier.endpage372en_US
dc.identifier.issn0024-7758
dc.identifier.issn1943-3565
dc.identifier.issue5en_US
dc.identifier.pmid15214710en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage368en_US
dc.identifier.urihttps://hdl.handle.net/11454/38168
dc.identifier.volume49en_US
dc.identifier.wosWOS:000221658600007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofJournal of Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlabor, prematureen_US
dc.subjectinsulin-like growth-factor-bindingen_US
dc.subjectprotein 1en_US
dc.subjectcervixen_US
dc.titleValue of cervical phosphorylated insulinlike growth factor binding protein-1 in the prediction of preterm laboren_US
dc.typeArticleen_US

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