Plasma levels of antioxidant vitamins in patients with acromegaly: A case-control study

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dc.contributor.authorKutbay N.O.
dc.contributor.authorYurekli B.S.
dc.contributor.authorSimsir I.Y.
dc.contributor.authorSuner A.
dc.contributor.authorSeckiner S.
dc.contributor.authorKucukerdonmez O.
dc.contributor.authorSaygili F.
dc.date.accessioned2021-05-03T20:51:53Z
dc.date.available2021-05-03T20:51:53Z
dc.date.issued2019
dc.description.abstractOBJECTIVE: The aim of this study was to compare antioxidant Vitamin C and Vitamin E levels in the non-acromegaly control group and in patients with acromegaly with and without remission. MATERIAL AND METHODS: In this study, 100 cases, acromegaly patients of 57% (n=57, 29F, 28M, mean ages of 49.5±12.1) and control subjects of 43% (n=43, 29F, 14M, mean ages of 49.6±9.2). Acromegaly patients were classified into two groups; active acromegaly (AA; n=33) and controlled acromegaly (CA; n=24). RESULTS: Vitamin C levels were significantly lower in the acromegaly group [7.6 (4.7) mg/L, as median (IQR)] when compared to the control group [12.2 (5.5) mg/L, as median (IQR)] (p <0.001). Vitamin E levels didn't show a significant difference between the acromegaly and the control groups (14.2±3.6 vs. 14.8±3.7, as mean±SD, respectively, p = 0.439). Correlation analysis showed that Vitamin C levels were not significantly associated with clinical, anthropometric and laboratory parameters in the acromegaly group. Vitamin E levels were significantly associated with the total cholesterol, triglyceride, LDL-C, HDL-C, APO Al, APO B both in the acromegaly and the control groups. CONCLUSION: This study is the first one to investigate the relationship between the levels of Vitamin C & E and anthropometric & metabolic parameters in acromegaly patients and control group. In our study, Vitamin C level was significantly lower in the acromegaly group compared to the level in the control group. There was no significant difference in Vitamin E levels between the acromegaly and control group. © 2019 Maghira and Maas Publications. All rights reserved.en_US
dc.identifier.endpage314en_US
dc.identifier.issn0172-780X
dc.identifier.issue7-8en_US
dc.identifier.pmid32304366en_US
dc.identifier.scopus2-s2.0-85084167711en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage308en_US
dc.identifier.urihttps://hdl.handle.net/11454/70944
dc.identifier.volume40en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMaghira and Maas Publicationsen_US
dc.relation.ispartofNeuroendocrinology Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectAnthropometric parametersen_US
dc.subjectAntioxidantsen_US
dc.subjectVitamin Cen_US
dc.subjectVitamin Een_US
dc.titlePlasma levels of antioxidant vitamins in patients with acromegaly: A case-control studyen_US
dc.typeArticleen_US

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