Demographic, clinical, and laboratory features of COVID-19 in children: The role of mean platelet volume in predicting hospitalization and severity

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dc.contributor.authorOzenen, Gizem Guner
dc.contributor.authorBal, Zumrut Sahbudak
dc.contributor.authorUmit, Zuhal
dc.contributor.authorBilen, Nimet Melis
dc.contributor.authorArslan, Sema Yildirim
dc.contributor.authorYurtseven, Ali
dc.contributor.authorOzkinay, Ferda
dc.date.accessioned2021-05-03T20:27:33Z
dc.date.available2021-05-03T20:27:33Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractThere have been a limited number of studies on coronavirus disease 2019 (COVID-19) in children. in this study, we aimed to investigate the demographic, clinical, and laboratory features of COVID-19 and to identify the role of mean platelet volume (MPV) in predicting the prognosis in children. A single-center retrospective study, including 251 confirmed and 65 suspected COVID-19 cases, was conducted between March 11, 2020, and December 11, 2020. in the confirmed COVID-19 group, 48 (19.1%) patients were asymptomatic, 183 (72.9%) mild, 16 (6.4%) moderate, 1 (0.4%) severe, and 3 were (1.2%) critically ill. Confirmed COVID-19 patients had significantly lower mean values of white blood cell (WBC), absolute neutrophil count, absolute lymphocyte count, platelet, and hemoglobin (p < .001). However, there was no significant difference in MPV levels between the two groups (p = .894). C-reactive protein (CRP), procalcitonin, fibrinogen, and NT-pro-BNP mean values were significantly lower in confirmed COVID-19 cases than suspected cases (p < .001). A total of 55 (21.9%) patients required hospitalization due to COVID-19, and MPV, WBC, CRP, procalcitonin, D-dimer, and NT-pro-BNP were statistically higher in hospitalized patients than those in outpatients. The multivariate analysis of confirmed COVID-19 cases according to the severity of disease showed that lymphopenia and higher levels of fibrinogen significantly associated with severe clinical symptoms. Decision tree analysis showed that the most powerful predictor of hospitalization due to COVID-19 was the D-dimer (p < .001). MPV values are not associated with COVID-19 disease severity. However, MPV can be used with other parameters such as WBC, CRP, procalcitonin, D-dimer, and NT-pro-BNP to predict hospitalization.en_US
dc.identifier.doi10.1002/jmv.26902en_US
dc.identifier.endpage3237en_US
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue5en_US
dc.identifier.pmid33629365en_US
dc.identifier.scopus2-s2.0-85102258905en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3227en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.26902
dc.identifier.urihttps://hdl.handle.net/11454/69557
dc.identifier.volume93en_US
dc.identifier.wosWOS:000627495100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID&#8208en_US
dc.subject19en_US
dc.subjectlymphopeniaen_US
dc.subjectmean platelet volumeen_US
dc.subjectpediatricsen_US
dc.titleDemographic, clinical, and laboratory features of COVID-19 in children: The role of mean platelet volume in predicting hospitalization and severityen_US
dc.typeArticleen_US

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