Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation

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dc.authorscopusid36112868100
dc.authorscopusid55357225500
dc.authorscopusid55469991100
dc.authorscopusid56604118900
dc.authorscopusid58098599600
dc.authorscopusid6506580350
dc.authorscopusid36615712900
dc.contributor.authorBagcioglu, E.
dc.contributor.authorSolmaz, V.
dc.contributor.authorErbas, O.
dc.contributor.authorÖzkul, B.
dc.contributor.authorÇakar, B.
dc.contributor.authorUyanikgil, Y.
dc.contributor.authorSöğüt, İ.
dc.date.accessioned2024-08-25T18:46:21Z
dc.date.available2024-08-25T18:46:21Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractTo evaluate the ameliorating effect of Modafinil on neuroinflammation, behavioral, and histopathological alterations in rats induced by propionic acid (PPA). Thirty male Wistar rats were used in the study, divided into 3 groups of ten subjects. One group served as a control, the subjects in the other two were given 250 mg/kg/day of PPA by intraperitoneal injection over the course of 5 days to induce autism. The experimental design was as follows: Group 1: Normal control (orally-fed control, n = 10); Group 2 (PPA + saline, n = 10): PPA and 1 ml/kg/day % 0.9 NaCl saline via oral gavage; Group 3 (PPA + Modafinil, n = 10) PPA and 30 mg/kg/day Modafinil (Modiodal tablets 100 mg, Cephalon) via oral gavage. All of the groups were investigated for behavioral, biochemical, and histological abnormality. Autism-like behaviors were reduced significantly in the rats treated with PPA. TNF-?, Nerve Growth Factor (NGF), IL-17, IL-2, and NF-KB levels as well as MDA levels and lactate were significantly higher in those treated with PPA compared to the control group. Using immunohistochemical methods, the number of neurons and GFAP immunoreactivity was significantly altered in PPA-treated rats compared to the control. Using Magnetic Resonance Spectroscopy (MRS), we found that lactate levels were significantly higher in the PPA-treated rats, while creatinine levels were significantly decreased. In the rats administered with Modafinil, behavior, neuroinflammation, and histopathological changes brought about by PPA were significantly reversed. Our results demonstrate the potential role of Modafinil in ameliorating PPA-induced neuroinflammation in rats. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.doi10.1007/s11481-023-10061-2
dc.identifier.issn1557-1890
dc.identifier.pmid37043086en_US
dc.identifier.scopus2-s2.0-85152403913en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1007/s11481-023-10061-2
dc.identifier.urihttps://hdl.handle.net/11454/101880
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Neuroimmune Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAutismen_US
dc.subjectModafinilen_US
dc.subjectNeuroinflammationen_US
dc.titleModafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammationen_US
dc.typeArticleen_US

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