Usefulness of N-terminal pro-B-type natriuretic peptide (NT-ProBNP) as a marker for cardiotoxicity and comparison with echocardiography in paediatric carbon monoxide poisoning

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dc.contributor.authorTuran, Caner
dc.contributor.authorDogan, Eser
dc.contributor.authorYurtseven, Ali
dc.contributor.authorSaz, Eylem Ulas
dc.date.accessioned2020-12-01T11:58:44Z
dc.date.available2020-12-01T11:58:44Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: To demonstrate the usefulness of N-Terminal Pro-B-Type natriuretic peptide (NT-proBNP) as an early biomarker of carbon monoxide-induced myocardial injury in children. It also aimed to identify the correlation between NT-proBNP and left ventricular systolic dysfunction findings shown by echocardiography. Methods: Prospective, observational study conducted at a paediatric emergency department between October 2017 and April 2019 which involved children aged 0-17 years. the patients were divided into three groups based on severity; mild, moderate and severe groups. the patient characteristics, carboxyhaemoglobin, CK-MB Mass (CKMB-M), troponin-T, and NT-proBNP levels were measured, and echocardiography was performed and left ventricular ejection fraction was measured. Results: Sixty-nine patients and 60 healthy controls were included. Male gender, younger age, higher carboxyhaemoglobin levels, and altered mental status were found as independent predictors of carbon monoxide-induced myocardial injury. If the cut-off value for NT-proBNP level is >480 pg/ml, the sensitivity-specificity for decreased left ventricular ejection fraction, which is the strongest carbon monoxide-induced myocardial injury sign, were 100-96%, respectively. A high negative correlation was found between NT-proBNP levels and left ventricular ejection fraction (r = -0.769, p < 0.01) in the carbon monoxide poisoning group, and there was a positive correlation between the carboxyhaemoglobin and NT-proBNP levels (r = 0.583, p < 0.01). Conclusion: Echocardiography is an ideal tool and very sensitive, but its routine use is limited due to its non-availability. An increased level of NT-proBNP (>480pg/ml) may be useful as an ideal biomarker for early detection of carbon monoxide-induced myocardial injury sign and reduced left ventricular ejection fraction which is the most crucial point in making a decision on hyperbaric oxygen therapy.en_US
dc.identifier.doi10.1017/S1047951120001651en_US
dc.identifier.endpage1108en_US
dc.identifier.issn1047-9511
dc.identifier.issn1467-1107
dc.identifier.issue8en_US
dc.identifier.pmid32571446en_US
dc.identifier.scopus2-s2.0-85089585364en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1103en_US
dc.identifier.urihttps://doi.org/10.1017/S1047951120001651
dc.identifier.urihttps://hdl.handle.net/11454/62095
dc.identifier.volume30en_US
dc.identifier.wosWOS:000562473300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCardiology in the Youngen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarbon monoxideen_US
dc.subjectNT-ProBNPen_US
dc.subjectechocardiographyen_US
dc.subjectmyocardial injuryen_US
dc.subjectchildrenen_US
dc.titleUsefulness of N-terminal pro-B-type natriuretic peptide (NT-ProBNP) as a marker for cardiotoxicity and comparison with echocardiography in paediatric carbon monoxide poisoningen_US
dc.typeArticleen_US

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