Tc-99m-Labeled, Colistin Encapsulated, Theranostic Liposomes for Pseudomonas aeruginosa Infection

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dc.authoridKarpuz, Merve/0000-0001-6681-2448
dc.authorscopusid57193741014
dc.authorscopusid57219215261
dc.authorscopusid56662137100
dc.authorscopusid57196047480
dc.authorscopusid57200229272
dc.authorscopusid35774636300
dc.authorscopusid57221835140
dc.contributor.authorKarpuz, Merve
dc.contributor.authorTemel, Aybala
dc.contributor.authorOzgenc, Emre
dc.contributor.authorTekintas, Yamac
dc.contributor.authorErel-Akbaba, Gulsah
dc.contributor.authorSenyigit, Zeynep
dc.contributor.authorAtlihan-Gundogdu, Evren
dc.date.accessioned2024-08-25T18:46:15Z
dc.date.available2024-08-25T18:46:15Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractInfectious diseases are still the major issue not only due to antibiotic resistance but also causing deaths if not diagnosed at early-stages. Different approaches including nanosized drug delivery systems and theranostics are researched to overcome antibiotic resistance, decrease the side effects of antibiotics, improve the treatment response, and early diagnose. Therefore, in the present study, nanosized, radiolabeled with Tc-99m, colistin encapsulated, neutral and cationic liposome formulations were prepared as the theranostic agent for Pseudomonas aeruginosa infections. Liposomes exhibited appropriate physicochemical properties thanks to their nano-particle size (between 173 and 217 nm), neutral zeta potential value (about - 6.5 and 2.8 mV), as well as encapsulation efficiency of about 75%. All liposome formulations were radiolabeled with over 90% efficiency, and the concentration of stannous chloride was found as 1 mg.mL(-1) to obtain maximum radiolabeling efficiency. In alamar blue analysis, neutral liposome formulations were found more biocompatible compared with the cationic formulations. Neutral colistin encapsulated liposomes were found to be more effective against P. aeruginosa strain according to their time-dependent antibacterial effect, in addition to their highest bacterial binding capacity. As conclusion, theranostic, nanosized, colistin encapsulated, neutral liposome formulations were found as promising agents for the imaging and treating of P. aeruginosa infections.en_US
dc.identifier.doi10.1208/s12249-023-02533-8
dc.identifier.issn1530-9932
dc.identifier.issue3en_US
dc.identifier.pmid36899198en_US
dc.identifier.scopus2-s2.0-85150002071en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1208/s12249-023-02533-8
dc.identifier.urihttps://hdl.handle.net/11454/101834
dc.identifier.volume24en_US
dc.identifier.wosWOS:000948765200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAaps Pharmscitechen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectcolistinen_US
dc.subjectliposomeen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjecttechnetium-99 men_US
dc.subjecttheranostic approachen_US
dc.subjectIn-Vitroen_US
dc.subjectAcinetobacter-Baumanniien_US
dc.subjectAntimicrobial Resistanceen_US
dc.subjectEnhanced Permeabilityen_US
dc.subjectMethanesulfonateen_US
dc.subjectDeliveryen_US
dc.subjectNanoparticlesen_US
dc.subjectTc-99men_US
dc.subjectPharmacokineticsen_US
dc.subjectPharmacodynamicsen_US
dc.titleTc-99m-Labeled, Colistin Encapsulated, Theranostic Liposomes for Pseudomonas aeruginosa Infectionen_US
dc.typeArticleen_US

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