Transferrin-Decorated Niosomes with Integrated InP/ZnS Quantum Dots and Magnetic Iron Oxide Nanoparticles: Dual Targeting and Imaging of Glioma

Basit Öğe Kaydı
dc.authoridCeylan, Ayse Elcin/0000-0002-0591-6080
dc.authoridBARLAS, Firat Baris/0000-0001-6401-686X
dc.authoridTimur, Suna/0000-0002-1981-7577
dc.authoridStahl, Frank/0000-0001-7416-0806
dc.authoridScheper, Thomas/0000-0003-1535-4584
dc.authorscopusid57211333020
dc.authorscopusid57211073551
dc.authorscopusid56174039400
dc.authorscopusid57200445635
dc.authorscopusid55845284000
dc.authorscopusid57211212139
dc.authorscopusid6701638388
dc.authorwosidCeylan, Ayse Elcin/ABB-2413-2020
dc.authorwosidBARLAS, Firat Baris/ABB-1223-2020
dc.authorwosidTimur, Suna/CAG-0914-2022
dc.contributor.authorAg Seleci, Didem
dc.contributor.authorMaurer, Viktor
dc.contributor.authorBarlas, Firat Baris
dc.contributor.authorPorsiel, Julian Cedric
dc.contributor.authorTemel, Bilal
dc.contributor.authorCeylan, Elcin
dc.contributor.authorTimur, Suna
dc.date.accessioned2023-01-12T20:15:36Z
dc.date.available2023-01-12T20:15:36Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractThe development of multifunctional nanoscale systems that can mediate efficient tumor targeting, together with high cellular internalization, is crucial for the diagnosis of glioma. The combination of imaging agents into one platform provides dual imaging and allows further surface modification with targeting ligands for specific glioma detection. Herein, transferrin (Tf)-decorated niosomes with integrated magnetic iron oxide nanoparticles (MIONs) and quantum dots (QDs) were formulated (PEGNIO/QDs/MIONs/Tf) for efficient imaging of glioma, supported by magnetic and active targeting. Transmission electron microscopy confirmed the complete co-encapsulation of MIONs and QDs in the niosomes. Flow cytometry analysis demonstrated enhanced cellular uptake of the niosomal formulation by glioma cells. In vitro imaging studies showed that PEGNIO/QDs/MIONs/Tf produces an obvious negative-contrast enhancement effect on glioma cells by magnetic resonance imaging (MRI) and also improved fluorescence intensity under fluorescence microscopy. This novel platform represents the first niosome-based system which combines magnetic nanoparticles and QDs, and has application potential in dual-targeted imaging of glioma.en_US
dc.description.sponsorshipNiedersachsisches Ministerium fur Wissenschaft und Kultur through the Quantum- and Nano-Metrology (QUANOMET) initiative [ZN3245, NP-1]; German Research Foundation; Open Access Publication Funds of Technische Universitat Braunschweigen_US
dc.description.sponsorshipThis research was partially funded by Niedersachsisches Ministerium fur Wissenschaft und Kultur through the Quantum- and Nano-Metrology (QUANOMET) initiative (ZN3245) within the project NP-1. Moreover, we acknowledge support from the German Research Foundation and the Open Access Publication Funds of Technische Universitat Braunschweig.en_US
dc.identifier.doi10.3390/ijms22094556
dc.identifier.issn1422-0067
dc.identifier.issue9en_US
dc.identifier.pmid33925347en_US
dc.identifier.scopus2-s2.0-85104753811en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/ijms22094556
dc.identifier.urihttps://hdl.handle.net/11454/78521
dc.identifier.volume22en_US
dc.identifier.wosWOS:000650428800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmultifunctional niosomesen_US
dc.subjectquantum dotsen_US
dc.subjectiron oxide nanoparticlesen_US
dc.subjectglioma imagingen_US
dc.subjectContrast Agentsen_US
dc.subjectDeliveryen_US
dc.subjectTherapyen_US
dc.subjectGlioblastomaen_US
dc.subjectReceptoren_US
dc.subjectHybridsen_US
dc.subjectBrainen_US
dc.titleTransferrin-Decorated Niosomes with Integrated InP/ZnS Quantum Dots and Magnetic Iron Oxide Nanoparticles: Dual Targeting and Imaging of Gliomaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu