Desensitization effect of preseasonal seven-injection allergoid immunotherapy with olive pollen on basophil activation: The efficacy of olive pollen-specific preseasonal allergoid immunotherapy on basophils

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dc.contributor.authorGokmen N.M.
dc.contributor.authorErsoy R.
dc.contributor.authorGulbahar O.
dc.contributor.authorArdeniz O.
dc.contributor.authorSin A.
dc.contributor.authorUnsel M.
dc.contributor.authorKokuludag A.
dc.date.accessioned2019-10-27T08:33:03Z
dc.date.available2019-10-27T08:33:03Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: It has previously been demonstrated that subcutaneous immunotherapy with allergoids positively affects clinical and immunological parameters even after 7 preseasonal injections. However, its effect on basophil activation remains unclear. We investigated the effect of preseasonal allergoid immunotherapy on basophils and concomitantly assessed its clinical and immunological efficacy in olive pollen-monosensitized patients. Methods: This study enrolled 437 consecutive patients with respiratory allergy and positive skin prick tests (SPTs); 212 (48.5%) patients were sensitized to olive pollen, and 33 (7.5%) patients were sensitized to olive pollen only. Of these patients, 23 received preseasonal immunotherapy with an olive pollen allergoid. The olive pollen-specific basophil activation, the titrated nasal provocation test, the nasal symptom score, and olive pollen-specific IgE, IgG1 and IgG4 levels were evaluated before immunotherapy and 8 months after the end of immunotherapy in the follow-up visit. Results: In comparison to baseline evaluation, 7 preseasonal injections of an allergoid resulted in a significant decrease in the percentage of basophils expressing CD63 (29 vs. 7%, respectively, p < 0.0001) and a significant increase in the titrated nasal provocative dose (1/10 vs. 1/1, respectively, p < 0.01). SPT induration diameters caused by an olive pollen extract decreased (12 mm at baseline vs. 5.5 mm at follow-up, p < 0.005), as did nasal symptom score (7 at baseline vs. 3 at follow-up, p < 0.01). Olive pollen-specific IgE (17.5 vs. 50 kU/l, p < 0.012), IgG1 (0.16 vs. 2.9 µg/ml, p < 0.0001) and IgG4 (0.07 vs. 1.92 µg/ml, p < 0.0001) levels significantly increased. Conclusions: Immunotherapy with 7 preseasonal injections of an olive pollen allergoid decreases olive pollen-specific basophil activation over 8 months, an effect observed in vitro and in vivo. Copyright © 2012 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000335251en_US
dc.identifier.endpage82en_US
dc.identifier.issn1018-2438
dc.identifier.issue1en_US
dc.identifier.pmid22572984en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1159/000335251
dc.identifier.urihttps://hdl.handle.net/11454/26632
dc.identifier.volume159en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAllergen-specific immunotherapyen_US
dc.subjectAllergen-specific nasal challengeen_US
dc.subjectAllergoiden_US
dc.subjectBasophil activation testen_US
dc.subjectOlea europaea pollenen_US
dc.titleDesensitization effect of preseasonal seven-injection allergoid immunotherapy with olive pollen on basophil activation: The efficacy of olive pollen-specific preseasonal allergoid immunotherapy on basophilsen_US
dc.typeArticleen_US

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