Testing of bioactive-nanovesicles on hepatotoxicity of atypical antipsychotics via digital holography

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dc.contributor.authorKirbay, Fatma Ozturk
dc.contributor.authorGeyik, Caner
dc.contributor.authorGuler, Emine
dc.contributor.authorYesiltepe, Ozan
dc.contributor.authorGumus, Zinar Pinar
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorTimur, Suna
dc.date.accessioned2019-10-27T11:09:12Z
dc.date.available2019-10-27T11:09:12Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractAtypical antipsychotic drugs induce hepatic toxicity. Thus, it is of importance to eliminate the side effects of these drugs. Herein we describe the preparation of nanoemulsions with a dietary supplement; wheat germ oil (WGO), to ameliorate the liver damage induced by clozapine and olanzapine. THLE-2 cell line was used as a model to investigate the effects of these nanoemulsions on cell viability as well as antioxidative efficiency after antipsychotic insult. In this context, a conventional cell culture method; MTT was used along with a novel cellular imaging technique called digital holography (DH) to evaluate cell viability. Obtained data confirmed that both clozapine and olanzapine induced the liver damage in in vitro model and WGO nanoemulsions were found to be effective on cells and eliminate the cytotoxic effects of these drugs. Briefly, this study has some outputs as follows; it showed that different dietary supplements can be used in such formulations instead of their pristine forms to increase bioavailability. Also, DH was successfully applied for the monitoring of cell viability and it could be a promising approach as the reactive-free cytotoxicity test. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [214Z126]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK), grant number 214Z126.en_US
dc.identifier.doi10.1016/j.colsurfb.2017.01.006en_US
dc.identifier.endpage295en_US
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid28126680en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2017.01.006
dc.identifier.urihttps://hdl.handle.net/11454/32263
dc.identifier.volume152en_US
dc.identifier.wosWOS:000398014100034en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofColloids and Surfaces B-Biointerfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNanovesiclesen_US
dc.subjectNanoemulsionsen_US
dc.subjectBioactive-nanostructuresen_US
dc.subjectViabilityen_US
dc.subjectDigital holography (DH)en_US
dc.subjectDietary supplementen_US
dc.titleTesting of bioactive-nanovesicles on hepatotoxicity of atypical antipsychotics via digital holographyen_US
dc.typeArticleen_US

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