Contradictory effects of chlorpromazine on endothelial cells in a rat model of endotoxic shock in association with its actions on serum TNF-? levels and antioxidant enzyme activities

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dc.contributor.authorCan C.
dc.contributor.authorDemirci B.
dc.contributor.authorUysal A.
dc.contributor.authorAkçay Y.D.
dc.contributor.authorKoşay S.
dc.date.accessioned2019-10-27T08:59:38Z
dc.date.available2019-10-27T08:59:38Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractWe examined the effects of the phenothiazine derivative, chlorpromazine on thoracic aortic endothelial cell histology (14h after LPS challenge) in a model of endotoxic shock in rats. Since excessive formation of tumor necrosis factor-? (TNF-?) and oxygen-derived free radicals contribute to endothelial injury in endotoxemia, we also evaluated the effect of the drug on the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase in liver tissue in this model and tried to find out whether this possible effect was associated with a change in serum TNF-? levels (measured 90min after chlorpromazine administration). Endotoxemia was induced by a single i.p. injection of lipopolysaccharide (LPS) (5mgkg-1 in 1.5ml of saline; LPS from Escherichia coli serotype 055:B5, L-2880, Sigma Chemical Company). Electron microscopic evaluation of the aortas revealed that chlorpromazine (administered 30min prior to LPS challenge), in smaller doses (3mgkg-1) ameliorated the endothelial cell injury caused by LPS, whereas it caused deterioration of endothelial cell morphology in higher doses (10 and 25mgkg-1). Chlorpromazine administration caused a significant reduction in serum TNF-? levels, which was correlated well with an increase in SOD activity in all drug doses (3, 10 and 25mgkg-1). Catalase activity was increased only in the 25mgkg-1 chlorpromazine group. © 2003 Elsevier Science Ltd. All rights reserved.en_US
dc.description.sponsorshipThis study was supported by the Ege University Research Found. --en_US
dc.identifier.doi10.1016/S1043-6618(03)00093-8en_US
dc.identifier.endpage230en_US
dc.identifier.issn1043-6618
dc.identifier.issue3en_US
dc.identifier.pmid12860438en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://doi.org/10.1016/S1043-6618(03)00093-8
dc.identifier.urihttps://hdl.handle.net/11454/27865
dc.identifier.volume48en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Pressen_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectChlorpromazineen_US
dc.subjectEndothelial cellen_US
dc.subjectEndotoxemiaen_US
dc.subjectTNF-?en_US
dc.titleContradictory effects of chlorpromazine on endothelial cells in a rat model of endotoxic shock in association with its actions on serum TNF-? levels and antioxidant enzyme activitiesen_US
dc.typeArticleen_US

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