Boronate affinity nanoparticles for nucleoside separation

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dc.contributor.authorOkutucu, Burcu
dc.contributor.authorVurmaz, Deniz
dc.contributor.authorTuncal, Akile
dc.contributor.authorTurkcan, Ceren
dc.contributor.authorUygun, Deniz Aktas
dc.contributor.authorAkgol, Sinan
dc.date.accessioned2019-10-27T23:11:54Z
dc.date.available2019-10-27T23:11:54Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractBoronate affinity systems have been recently used for the specific isolation of cis-diol group carrying biomolecules such as glycoproteins, nucleosides, carbohydrates. Nanosized materials have been extremely used for the biotechnological purposes due to their unique properties and their high surface areas. The objective of this presented work was to develop a new boronate affinity system for the nucleoside adsorption. For this purpose, poly(HEMA) nanoparticles were synthesized by using surfactant free emulsion polymerization technique and then functionalized with phenylboronic acid. Synthesized nanoparticles were characterized with FTIR, SEM, and Zeta size analysis. Nucleic acid adsorption experiments were repeated for different medium pH values, for various nucleosides concentrations, for different temperatures and ionic strengths, in order to determine the optimum adsorption conditions. In the light of these studies, it can be concluded that this boronate ligand carrying nanoparticles were very valuable for the separation of nucleosides.en_US
dc.identifier.doi10.3109/21691401.2014.948550en_US
dc.identifier.endpage327en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue1en_US
dc.identifier.pmid25137488en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage322en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2014.948550
dc.identifier.urihttps://hdl.handle.net/11454/53143
dc.identifier.volume44en_US
dc.identifier.wosWOS:000368022400042en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArtificial Cells Nanomedicine and Biotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectboronate affinityen_US
dc.subjectnanoparticleen_US
dc.subjectnucleosideen_US
dc.subjectphenylboronic aciden_US
dc.titleBoronate affinity nanoparticles for nucleoside separationen_US
dc.typeArticleen_US

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